Design, development, and characterization of liposomes loaded with cefuroxime

Varshini Madda; Narendra Devanaboyina; Naga Santhosh Reddy Satti; Eswari Bezawada; Veerendra Kumar D; Durga Prasad Reddy Sathi; Abhinav VKS Grandhi

doi:10.47957/ijpda.v13i2.626

Authors

Madda Varshini Assistant Professor, Department of Pharmaceutics, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
Devanaboyina Narendra Principal and Professor, Department of Pharmacognosy, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
Satti Naga Santhosh Reddy III/IV, Bachelor of Pharmacy, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
Bezawada Eswari Associate Professor, Department of Pharmaceutics, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
D Veerendra Kumar Associate Professor, Department of Pharmacy Practice, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
Sathi Durga Prasad Reddy Assistant Professor, Department of Pharmacology, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.
Abhinav VKS Grandhi Assistant Professor, Department of Pharmacy Practice, VJ’s College of Pharmacy, Diwancheruvu, Rajahmundry - 533296, Andhra Pradesh, India.

DOI:

https://doi.org/10.47957/ijpda.v13i2.626

Keywords:

Liposomes, Differential Scanning Calorimetry (DSC), Cefuroxime, Drug delivery system, Encapsulation efficiency (EE)

Abstract

Liposomes have emerged as a promising drug delivery system due to their biocompatibility, biodegradability, and ability to enhance drug stability while minimising adverse effects. This study focuses on the formulation and characterisation of cefuroxime-loaded liposomes prepared using the thin lipid film hydration method. Nine formulations were developed using varying concentrations of soya lecithin and cholesterol, followed by vortexing for different durations. The prepared liposomes were evaluated for drug-excipient compatibility using DSC, particle size distribution, zeta potential, drug entrapment efficiency, and in vitro drug release kinetics. The optimized formulation (F9) demonstrated high drug entrapment efficiency (87.36%), nanoscale particle size (1246.4 nm), and a stable zeta potential (-47.2 mV). In vitro release studies revealed a controlled and sustained drug release profile following zero-order kinetics. The results indicate that increasing lipid concentration enhances drug encapsulation but slows drug release. These findings highlight the potential of liposomal formulations for improving cefuroxime delivery, stability, and therapeutic efficacy.

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