Computational Analysis Studies On Chalcone Derivatives As Anticonvulsant Agent

Abstract

In the present study, twenty eight compounds from literature were docked into receptor GABA 1AZM, compound XXVII was found to be most potent followed by XXII, XX, XXIV, XIX, XXVIII showed highest moldock score or low binding energy and good hydrogen bond interaction. Further in silico lipophillic profile were carried out using Marvin Sketch v 5.1 and found that compound XXVII followed by others possessed the entire theoretical drug like properties. Thus provide a way to synthesize such compounds and their derivatives and evaluate them for anticonvulsant activity in vivo.