Nanoradiopharmaceuticals and radiation-based nano systems for imaging and therapeutic applications

Authors

  • Are.Pradeepthi Assistant Professor, Department of Pharmaceutics, St. Ann’s College of Pharmacy, Chirala.

DOI:

https://doi.org/10.47957/ijpda.v13i1.619

Keywords:

Nano-radiopharmaceuticals, Radiation-based nanosystems, Medical imaging, Targeted therapy, Molecular imaging, Personalized medicine

Abstract

Nano-radiopharmaceuticals and radiation-based nanosystems represent an innovative frontier in the field of medical imaging and therapy. These advanced technologies harness the unique properties of nanomaterials and radioactive isotopes to provide highly targeted diagnostic and therapeutic solutions. Nano-radiopharmaceuticals combine the precision of nanotechnology with the effectiveness of radiation to improve the delivery of radioactive agents to specific sites within the body, enhancing imaging contrast and therapeutic outcomes. These systems can be used for molecular imaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), offering high-resolution, real-time imaging of cellular and tissue-level processes. In therapy, radiation-based nanosystems, such as radiolabeled nanoparticles, are designed to selectively irradiate cancerous cells, reducing damage to surrounding healthy tissues. Furthermore, these nanostructures enable the controlled release of radiation doses, improving treatment efficacy while minimizing side effects. The development of multifunctional nanosystems that integrate diagnostic imaging with therapeutic actions holds great promise for personalized medicine, paving the way for more effective and precise treatments in oncology, neurology, and other fields. However, biocompatibility, stability, and safety must be addressed to translate these technologies into clinical practice. Future research aims to optimize the design of nano-radiopharmaceuticals and radiation-based nanosystems to maximize their therapeutic potential while ensuring minimal toxicity.

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References

Jain, S., Hirst, D. G., & O'Sullivan, J. M. (2012). "Gold nanoparticles as novel agents for cancer therapy." The British Journal of Radiology, 85(1010), 101-113.

doi:10.1259/bjr/59448833

Song, G., Cheng, L., Chao, Y., & Yang, K. (2017). "Emerging nanotechnology and advanced materials for cancer radiation therapy." Advanced Materials, 29(32), 1700996.doi:10.1002/adma.201700996

Chakravarty, R., Goel, S., & Cai, W. (2014). "Nanobody: the 'magic bullet' for molecular imaging?" Theranostics, 4(4), 386-398.doi:10.7150/thno.8006

Her, S., Jaffray, D. A., & Allen, C. (2017). "Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements." Advanced Drug Delivery Reviews, 109, 84-101.doi:10.1016/j.addr.2016.11.006

Schuemann, J., Berbeco, R., Chattopadhyay, N., & Kumar, R. (2020). "Nanoparticles for cancer treatment: precision radiotherapy with new horizons." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 12(1), e1576.doi:10.1002/wnan.1576

Prasad, R. Y., Wallace, K., Daniel, S., & Tennant, A. H. (2013). "Nanoparticles as radiation sensitizers: A review of experimental and clinical studies." Journal of Nanoscience and Nanotechnology, 13(1), 1-13.doi:10.1166/jnn.2013.6896

Chen, W., Zhang, S., Yu, Y., & Zhang, H. (2019). "Nanotechnology in radiotherapy for gastrointestinal cancers." Nanomedicine: Nanotechnology, Biology, and Medicine, 20, 102030.doi:10.1016/j.nano.2019.102030

Dadachova, E., & Mirzadeh, S. (2020). "Nanotechnology in targeted radionuclide therapy." Molecular Imaging and Biology, 22, 421-429.

doi:10.1007/s11307-019-01391-w

Rosenkranz, A. A., Slastnikova, T. A., Durymanov, M. O., & Sobolev, A. S. (2014). "Targeted intracellular delivery of radiopharmaceuticals for cancer treatment." Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1846(1), 239-257.

doi:10.1016/j.bbcan.2014.07.002

Thakor, A. S., & Gambhir, S. S. (2013). "Nanooncology: The future of cancer diagnosis and therapy." CA: A Cancer Journal for Clinicians, 63(6), 395-418.doi:10.3322/caac.21199

Jiang, Y., Huo, S., Mizuhara, T., Das, R., & Rotello, V. M. (2015). "Nanotechnology in radiation therapy: From bench to bedside." Bioconjugate Chemistry, 26(6), 1142-1153.doi:10.1021/acs.bioconjchem.5b00119

Barreto, J. A., O'Malley, W., Kubeil, M., Graham, B., Stephan, H., &Spiccia, L. (2011). "Nanomaterials: Applications in cancer imaging and therapy." Advanced Materials, 23(12),H18-H40.doi:10.1002/adma.201004496

Akhtar, N., Akram, M., Daniyal, M., & Ahmad, S. (2018). Evaluation of antidiabetic activity of Ipomoea batatas L. extract in alloxan-induced diabetic rats. International Journal of Immunopathology and Pharmacology, 32, 205873841881467. https://doi.org/10.1177/2058738418814678

Ranjith, D., & Viswanath, S. (2019). In silico antidiabetic activity of bioactive compounds in Ipomoea mauritiana Jacq [Journal-article]. The Pharma Innovation Journal, 8–10, 05–11.

Rauniyar, N., & Srivastava, D. (2020). Ipomoea digitata: A therapeutic boon from nature to mankind. The Journal of Indian Botanical Society, 100(3and4), 185–191. https://doi.org/10.5958/2455-7218.2020.00039.x

Published

2025-03-11
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How to Cite

Are, P. “Nanoradiopharmaceuticals and Radiation-Based Nano Systems for Imaging and Therapeutic Applications”. International Journal of Pharmaceutics and Drug Analysis, vol. 13, no. 1, Mar. 2025, pp. 17-22, doi:10.47957/ijpda.v13i1.619.

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