Preparation and evalution of sustained release matrix tablet of nitrofurantoin

Harpreet Singh Arora; Taranjit Kaur; Rajesh Kumar; Amar Pal Singh; Singh Singh

doi:10.47957/ijpda.v13i1.616

Authors

Harpreet Singh Arora Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Taranjit Kaur Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Rajesh Kumar Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Amar Pal Singh Department of Pharmacology, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Ajeet Pal Singh 1Department of Pharmaceutics, St. Soldier Institute of Pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

DOI:

https://doi.org/10.47957/ijpda.v13i1.616

Keywords:

Nitrofurantoin, Bioavailability, matrix, sustained release, characterization

Abstract

In the present study an attempt was made to Preparation and Evaluation of Sustained Release Matrix Tablet of Nitrofurantoin by wet granulation method using various polymers like HPMC 4000 & PVPK 30

Materials and Methods

A variety of physicochemical characteristics, including rheological characteristics, weight variation, thickness, hardness, in vitro release studies, and drug content, were assessed for the prepared tablets.

Results

All of the physicochemical parameters met the official standards, according to studies. The extended release profile of the formulation, which has better bioavailability and lower dosing frequency with lower doses, is confirmed by the in vitro release studies, which show release up to 90.02 % over an extended period of time.

Conclusion

Nitrofurantoin sustained release matrix tablets have shown improved potency, efficacy, and bioavailability. According to the drug release study, PVPK 30 and HPMC4000 could maintain the drug release. The drug release was sustained for over twenty-four hours when both polymers were combined with the drug.

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References

Nitrofurantoin has a low absolute bioavailability and a comparatively short plasma half-life. Patient compliance may be lowered if larger doses must be administered two or three times per day. For daily dosing of nitrofurantoin, a sustained release formulation that would sustain plasma levels for 8–24 hours might be adequate. For nitrofurantoin to increase patient compliance and extend its duration of action, sustained release products are required. This study's main goal was to create an oral sustained-release nitrofurantoin tablet using the combination of HPMC4000 and PVPK30 as a rate-controlling factor. According to the drug release study, PVPK 30 and HPMC4000 could maintain the drug release. The drug release was maintained for over twenty-four hours when both polymers were combined with the drug.

DisclosureStatement

There are no conflicts of interest.

Acknowledgment

It’s our privilege to express the profound sense of gratitude and cordial thanks to our respected chairman Mr. Anil Chopra and Vice Chairperson Ms. Sangeeta Chopra, St. Soldier Educational Society, Jalandhar for providing the necessary facilities to complete this research work.

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