Formulation of Antibacterial Mouthwashes Based On an Aqueous Extract of the Leaves of Prosopis Africana (Guill. Et Perr.) Taub (Fabaceae)

Salfo Ouédraogo; Tata Kadiatou  Traoré; Safiatou Traoré; Moussa  Tiabondou; Manégrebem Adèle  Ouédraogo; Boladé Constantin  Atchadé; Alimata Bancé; Ayé Monique  Neya; Boumbéwendin Gérard Josias  Yaméogo; Rasmané Semdé

doi:10.47957/ijpda.v13i2.615

Authors

Salfo Ouédraogo Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.
Tata Kadiatou Traoré Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.
Safiatou Traoré Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.
Moussa Tiabondou Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.
Manégrebem Adèle Ouédraogo Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.
Boladé Constantin Atchadé Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso
Alimata Bancé Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.
Ayé Monique Neya Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.
Boumbéwendin Gérard Josias Yaméogo Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.
Rasmané Semdé Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.

DOI:

https://doi.org/10.47957/ijpda.v13i2.615

Keywords:

Oral pathogens, Prosopis africana extracts, mouthwashes, Phytochemicals, Antimicrobial activity

Abstract

The aim of this work was to propose an antibacterial mouthwash formulation based on aqueous extracts of the leaves of Prosopis africana (Fabaceae) for maintaining oral hygiene. Three types of mouthwashes were formulated, incorporating the liquid extract, freeze-dried extract, and oven-dried liquid extract of Prosopis africana as the active ingredient. Quality control of the formulations involved the evaluation of macroscopic and organoleptic characteristics, pH, phytochemical composition, and in vitro antimicrobial activity. The mouthwashes were liquid in consistency, clear in appearance, homogeneously green in color, with a menthol odor and a sweet taste. The pH values ranged from 5.05?±?0.03 for the mouthwash formulated with the liquid extract, 5.24?±?0.1 for the mouthwash formulated with the oven-dried extract, and 5.18?±?0.01 for the mouthwash formulated with the freeze-dried extract. The formulations containing the liquid extract showed higher levels of phytochemical content. All formulated mouthwashes exhibited broad-spectrum antimicrobial activity against the tested oral pathogens.

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Author Biographies

Salfo Ouédraogo, Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.

Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso. and Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.

Safiatou Traoré, Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso.

Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso and Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.

Boladé Constantin Atchadé, Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso

Laboratoire de Recherche-Développement de phytomédicaments et médicaments (LR-D/PM), Institut de recherche en sciences de la santé (IRSS/CNRST), 03 BP 7047 Ouaga 03, Burkina Faso and Laboratoire du Développement des médicaments (LADME), École doctorale de la santé, Université Joseph Ki-Zerbo, 03 BP 7021 Ouaga 03, Burkina Faso.

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