Drug penetration enhancement via skin in transdermal drug delivery through stratum corneum- QSAR Modeling

Abstract

The objective of this work was to develop a Quantitative Structure Activity Relationship (QSAR) model for understanding
the effect of topological polar surface area, lipo-affinity index, fragment complexity and MLogP on the drug penetration
power of penetration enhancers. For developing the model, Multiple Linear Regression (MLR) has been employed as an
effective and efficient method and this model has been validated with statistical analysis such as fraction of variance, cross
validation test, quality factor, standard deviation, and internal validation test. A regression based QSAR model has been
developed with cross validation test q2 = 0.914 and fraction of variance r2 = 0.913, i.e. >90% predictive efficiency and all
the statistical tests have validated this model.