Drug penetration enhancement via skin in transdermal drug delivery through stratum corneum- QSAR Modeling

Authors

  • VISHAL SHARMA, AJEET Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar 251001, India
  • ARVIND KUMAR Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar 251001, India

Keywords:

penetration enhancer; partition coefficient, topological polar surface area; lipo-affinity index; Fragment Complexity

Abstract

The objective of this work was to develop a Quantitative Structure Activity Relationship (QSAR) model for understanding
the effect of topological polar surface area, lipo-affinity index, fragment complexity and MLogP on the drug penetration
power of penetration enhancers. For developing the model, Multiple Linear Regression (MLR) has been employed as an
effective and efficient method and this model has been validated with statistical analysis such as fraction of variance, cross
validation test, quality factor, standard deviation, and internal validation test. A regression based QSAR model has been
developed with cross validation test q2 = 0.914 and fraction of variance r2 = 0.913, i.e. >90% predictive efficiency and all
the statistical tests have validated this model.

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Published

2014-05-12
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How to Cite

VISHAL SHARMA, AJEET, and ARVIND KUMAR. “Drug Penetration Enhancement via Skin in Transdermal Drug Delivery through Stratum Corneum- QSAR Modeling”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 5, May 2014, pp. 389-98, https://ijpda.org/index.php/journal/article/view/61.

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Research Articles
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