Development of simple uv-spectrophotometric method for the estimation of vildagliptin drug in bulk and its formulation

Ramakrishna M; Suresh Kumar J.N; Durga Sahithi S; Goushabi SK; Meghana Haritha M; Krishnaveni T; Gopi Y

doi:10.47957/ijpda.v12i1.581

Authors

Ramakrishna.M Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Suresh Kumar.J.N Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Durga Sahithi.S Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Goushabi.SK Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Meghana Haritha.M Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Krishnaveni.T Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
Gopi.Y Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India

DOI:

https://doi.org/10.47957/ijpda.v12i1.581

Keywords:

UV spectroscopy, Method development, Validation and Formulation

Abstract

The purpose of the investigation is to develop a simple, rapid, accurate, and precise UV-Spectrophotometric method for the estimation of Vildagliptin in bulk and formulations. The validation of the developed method was carried out according to ICH guidelines concerning linearity, precision, accuracy, the limit of detection, and the limit of quantification, formulation linearity. Calibration curves were obtained in the concentration range of 5 to 30µg/ml for Vildagliptin and with good correlation coefficients (R²=0.9995). The precisions of the new method for the drug were less than the maximum allowable limit (%RSD <2.0) specified by the ICH. Therefore, the method was found to be accurate, reproducible, and sensitive for analysis of Vildagliptin in bulk and formulations.

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