Development of simple uv-spectrophotometric method for the estimation of vildagliptin drug in bulk and its formulation
DOI:
https://doi.org/10.47957/ijpda.v12i1.581Keywords:
UV spectroscopy, Method development, Validation and FormulationAbstract
The purpose of the investigation is to develop a simple, rapid, accurate, and precise UV-Spectrophotometric method for the estimation of Vildagliptin in bulk and formulations. The validation of the developed method was carried out according to ICH guidelines concerning linearity, precision, accuracy, the limit of detection, and the limit of quantification, formulation linearity. Calibration curves were obtained in the concentration range of 5 to 30µg/ml for Vildagliptin and with good correlation coefficients (R2=0.9995). The precisions of the new method for the drug were less than the maximum allowable limit (%RSD <2.0) specified by the ICH. Therefore, the method was found to be accurate, reproducible, and sensitive for analysis of Vildagliptin in bulk and formulations.
Downloads
References
Gundala U, Bhuvanagiri CS, Nayakanti D. Simultaneous estimation of vildagliptin and metformin in bulk and pharmaceutical formulations by UV spectrophotometry. American Journal of PharmTech Research. 2013; 3(1):338-45.
Prasad PV, Divya K, Ramana MV, Krishnaveni A, Vinay J, Mahadeswar M. Analytical method development and validation for the estimation of vildagliptin in bulk and its dosage form using UV spectrophotometer. IAJPR. 2017; 7(12):2231-6876.
Naveed S, Rehman H, Qamar F, Zainab S. Method development and validation of Vildagliptin using UV spectrophotometer. International Journal of Pharma Sciences and Research. 2014; 5(10):714-7.
Attimarad M, Venugopala KN, Al-Dhubiab BE, Elgorashe RE, Shafi S. Development of eco-friendly derivative spectrophotometric methods for the simultaneous quantitative analysis of remogliflozin and vildagliptin from formulation. Molecules. 2021 Oct 12; 26(20):6160.
Housheh S, Mohammad H, Alahmad Y. Spectrophotometric method for the determination of vildagliptin in bulk and pharmaceutical dosage forms. Int J Pharm Sci Rev Res. 2019; 17:117-20.
Mane SV, Khan MA. Development of UV-Visible spectrophotometric method for the estimation of vildagliptin in different medium. Journal of Pharmaceutical and Biological Sciences. 2022; 10(2):83-7.
Joshi P, Kotadiya R. Simultaneous estimation of remogliflozin etabonate and vildagliptin in a tablet formulation: UV spectrophotometric and HPLC-PDA method.
Sen AK, Khatariya SB, Sen DB, Maheshwari RA, Zanwar AS, Velmurugan R. Various innovative UV spectroscopic methodologies for concurrent estimation of dapagliflozin and vildagliptin in combined tablet. Journal of Applied Pharmaceutical Science. 2023 Sep 4; 13(9):213-23.
Narkhede MT, Rane SS, Chaudhari RY, Patil VR. DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF VILDAGLIPTIN AND METFORMIN IN BULK DRUGS AND PHARMACEUTICAL DOSAGE FORM.
Raveendra KS, Gaffar SM, Kalyane NV. First derivative spectrophotometric simultaneous determination of vildagliptin and metformin in tablet formulations. Pharmacophore. 2016 Mar 1; 7(2):109-17.
Shrikrishna B, Mulgund SV, Ranpise NS. Simultaneous spectrophotometric estimation of vildagliptin and metformin in bulk and tablet dosage form. Der Pharma Chemica. 2013; 5(1):24-7.
Panchal J, Dhaduk B, Dhalani J. STABILITY INDICATING ISOCRATIC RP-HPLC AND SECOND DERIVATIVE UV SPECTROSCOPIC METHODS FOR SIMULTANEOUS DETERMINATION OF REMOGLIFLOZIN ETABONATE AND VILDAGLIPTIN HYDROCHLORIDE. Rasayan Journal of Chemistry. 2023 Apr 1; 16(2).
Tiwari A, Sethi VA, Siddiqui AW, Panigrahy BK, Khuroo AH, Tyagi LK. BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF VILDAGLIPTIN IN RAT PLASMA USING LCMS/MS METHOD. Journal of Advanced Scientific Research. 2019 Aug 10; 10(03):22-9.
Dayoub LA, Amali F. Development of a new visible Spectrophotometric analytical method for determination of Vildagliptin in bulk and Pharmaceutical dosage forms. Research Journal of Pharmacy and Technology. 2020; 13(6):2807-10.
Rao KH, Rao AL, Sekhar KB. DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE ESTIMATION OF VILDAGLIPTIN IN PHARMACEUTICAL DOSAGE FORM. International Journal of Pharmaceutical, Chemical & Biological Sciences. 2014 Apr 1; 4(2).
Polyakova EB, Sabirzyanov DR, Prozorova NA, Foteeva AV. Physicochemical properties and methods of analysis of vildagliptin. Pharmaceutical Chemistry Journal. 2022 Apr; 56(1):110-7.
Boovizhikannan T, Palanirajan VK. RP-HPLC determination of vildagliptin in pure and in tablet formulation. Journal of pharmacy research. 2013 Jan 1; 7(1):113-6.
Ferrazza Alves Giordani C, Campanharo S, Ribeiro Wingert N, Maronesi Bueno L, Wittckind Manoel J, Virginia Garcia C, Maria Volpato N, Dineck Iop G, de Azevedo Mello P, Marlon de Moraes Flores E, Eva Scherman Schapoval E. UPLC-ESI/Q-TOF MS/MS method for determination of vildagliptin and its organic impurities. Journal of Chromatographic Science. 2020 Aug 21; 58(8):718-25.
Attimarad M, Islam MM, Shafi S, David M, Rahman A, Molina EI. Smart eco-friendly mathematically manipulated UV spectroscopic methods to resolve severely overlapped spectra of a binary mixture of dapagliflozin with sitagliptin and vildagliptin. Microchemical Journal. 2023 Jul 1; 190:108700.
Afaque Ansari, Ravishankar Chadchankar, Vaibhav Jadhav, Shivprasad Patil. UV Spectroscopy method development and validation for determination of Vildagliptin in bulk and formulation, World journal of pharmacy and pharmaceutical sciences. 2022; 11[5]:2154-2161.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.