Formulation and in-vitro evaluation of floating pulsatile drug delivery of chronotherapeutic release of h2 receptor antagonist of famotidine
DOI:
https://doi.org/10.47957/ijpda.v11i3.558Keywords:
Famotidine, Flaoting, Pulsatile, HPMCAbstract
In the present study famotidine floating pulsatile drug delivery system was developed. Various type and different concentrations of superdisintegrants and polymer affect the drug release. FTIR studies concluded that there is no interaction between drug and excipients. Based on disintegration time and dissolution time the formulation (F2) which contains 8% sodium starch glycollate was optimised. The optimised formulation F2 was further coated with different concentrations of HPMC K4M,HPMC K 15M and HPMC K 100M..Based on the concentration of the coating layer and solubility of the coating layer and the dissolution data the formulation (F6) which was coated with 150mg of HPMC K 15M was optimised.
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