Studies on the cardioprotective actions of myrcetin and kaempferol in ischemia reperfusion induced myocardial infarction in normal and stz induced type-i diabetic rats
Keywords:
Myocardial infarction, ischemia reperfusion, myrcetin, kaempferol, anti-oxidantsAbstract
Diabetic individuals are at increased risk for cardiovascular morbidity and mortality compared to the general population and portends a worse prognosis. Patients with type 1 diabetes exhibit a risk of cardiovascular mortality up to 10 times higher than non-diabetic subjects. As a result, diabetics are more likely to encounter situations of myocardial ischemia and reperfusion. Flavonoids such as Myricetin and Kaempferol have received much attention in the area of nutritional biology .In spite of tremendous potentiality of Myricetin and Kaempferol to protect the heart during ischemia-reperfusion, only few studies reported the cardioprotective actions of Myricetin and Kaempferol in ischemia reperfusion injury. However, cardioprotective mechanisms of Myricetin and Kaempferol have not been so far explored in ischemia-reperfusion of diabetic hearts. The objective of the present investigation is to evaluate the cardioprotective actions and mechanisms of Myricetin and Kaempferol against ischemia reperfusion injury in both normal and diabetic rats
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