Measurement Of Dementia Using Medicinal Plants For Cognitive Impairment
Keywords:
Dementia, total phenolics, leaves, Tinospora cordiofoliaAbstract
Dementia is a condition that is more widespread in aged. It involves a decline in their ability to think, or cognition, and memory. The present study was conducted to evaluate the presence of bioanalytes using different methods in the edible part extracts of Tinospora cordiofolia by ELISA method. Enzymatic assay of esterase, choline esterase and acetylcholine esterase were detected as 36.67, 17.43 and 65.45 % in triplicates assay. Analysis of the edible parts leaves Tinospora cordiofolia confirmed the presence of total phenolics content were found to be greater in support of drug development against deficits of learning and memory. Our finding suggests that leaves parts use in Tinospora cordiofolia are proficient with redox potentials, immunostimulation and for cognitive impairment.
Downloads
References
Panchabhai TS UPK, Rege N N. Validation of Therapeutic Claims of Tinospora cordifolia: A Review. Phytother Res. 2008; 22:425–41.
Hossain Md. Mokarram SMRH, Akter Raushanara Md., Islam Nurul MJR, Saha Moni Rani, Hoque Md. Ehsanul, Mazumder SR. Evaluation of analgesic and neuropharmacological properties of the aerial part of Tinospora cordifolia Miers. in mice. Stanford Journal of Pharmaceutical Sciences. 2009;2(2):31–37.
Gabrovska, K.; Marinov, I.; Godjevargova, T.; Portaccio, M.; Lepore, M.; Grano, V.; Dianoc N; Mita, G.M. The influence of the support nature on the kinetics parameters, inhibition constants and reactivation of immobilized acetylcholinesterase. Int. J. Biol. Macromol. 2008, 43, 339–345. 6.
Costa, P.; Gonçalves, S.; Valentao, P.; Andrade, P.B.; Romano, A. Accumulation of phenolic compounds in in vitro cultures and wild plants of Lavandula viridis L'Hér and their antioxidant and anti-cholinesterase potential. Food Chem. Toxicol. 2013, 57, 69–74.
Ellman, G.L., Courteney, K.D., Valentino, A.J., Featherstone, R.M. A new and rapid colorimeteric determi-nation of acetylcholinesterase activity. Biochem. Pharmacol. 1961, 7, 88–95
Gupta, A.; Gupta, R. A survey of plants for presence of cholinesterase activity. Phytochemistry 1997, 46, 827–831.
Singh SS, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC. Chemistry and medicinal properties of Tinospora Cordifolia (Guduchi) Indian J Pharmacol. 2003;35:83–91.
Shekhar C, Kumar S. (Kinetics of Acetylcholinesterase Inhibition by an Aqueous Extract of Mentha longifolia Leaves). Int. J. Pharm. Sci. Drug Res, 2014; 6(4): 348-50.
van Asperen, K. 1962. A study of housefly esterases by means of a sensitive colorimetric method. J. In-sect.Physiol.8:401-416.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edition). Arlington, US: American Psychiatric Publishing Inc., 2000
Preston G . Dementia in elderly adults. Prevalence and institutionalization. J Gerontol1986;41:261–7.
Ainsworth EA, Gillespie KM. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin- Ciocalteu reagent. Nat Protoc. 2007; 2(4):875–877.
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
