XAV-939 Suppress Metastasis By Inhibiting Breast Cancer Stem Cells
Keywords:
Cancer Stem Cell, 3D Mammosphere, Wnt/?-catenin, metastasis, CD44 /CD24Abstract
Dysfunctions of Wnt, Hedgehog and Notch pathways are evident in multiple tumor types and malignancies. A number of studies have suggested that dysregulation of Wnt/?-catenin signaling occurs in human breast cancer. Specifically, inhibition of Wnt/ ?-catenin pathway is implicated in arresting of cancer stem cells (CSCs), a small subset of cancer cells capable of self-renewal and differentiation into heterogeneous tumor cells. Here, we investigated tumor initiating property of breast cancer stem cell in-vitro with XAV-939 an inhibitor of Wnt/?-catenin signaling pathway. Targeting Wnt/?-catenin signaling with this inhibitor represents a promising strategy to suppress metastasis.
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