Cytogenetic Screening in Colorectal Cancer Patients of Tamil Nadu Population

Padma M; Nimmisha. E; Sasikala P; Dhivya.V; Balachandar.V; Ganesan.S

Authors

Padma M PG & Research Department of Zoology and Biotechnology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur-613503, Tamil Nadu, India
Nimmisha. E Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore – 641046, Tamil Nadu, India
Sasikala P PG & Research Department of Zoology and Biotechnology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur-613503, Tamil Nadu, India
Dhivya.V Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore – 641046, Tamil Nadu, India
Balachandar.V Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore – 641046, Tamil Nadu, India
Ganesan.S PG & Research Department of Zoology and Biotechnology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi, Thanjavur-613503, Tamil Nadu, India

Keywords:

Colorectal Cancer (CRC), Chromosomal aberrations (CAs), deletion, Tamil Nadu

Abstract

Colorectal cancer (CRC) is one of the most common types of cancer worldwide and harbors distinct chromosomal alterations. This study tries to investigate clinic-pathological, chromosomal alterations to identify the novel genes and expression pattern in Tamil Nadu population of CRC patients. Patients with CRC (n= 13) and healthy controls (n= 13) were evaluated by analyzing the chromosomal alterations by standard protocols. Higher percentage of deletions was found with 46, XY, del 18p- and translocation was 46, XY. In conclusion, correlation of focal chromosomal alterations enriched in cancer genes with its clinical outcome indicates a prognostic index contributing to drive the process of CRC.

Downloads

Download data is not yet available.

References

Jasperson KW, Tuohy TM, Neklason DW et al. Hereditary and familial colon cancer. Gastroenterol. 2010; 138: 2044–2058

ZainalAriffin O, Nor Saleha IT. National Cancer Registry Report 2007 Malaysia: Ministry of Health.

Notani PN . Global variation in cancer incidence and mortality. Curr Sci. 2001 ; 81: 465–474

Jemal A, Bray F, Center MM et al. Global cancer statistics. CA Cancer J Clin . 2011; 61: 69–90

Sung JJ, Lau JY, Goh KL, Leung WK et al. Asia Pacific Working Group on Colorectal Cancer. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol . 2005; 6:871–6

Jennifer H Lin, Edward Giovannucci. Sex Hormones and Colorectal Cancer: What Have We Learned So Far. J Natl Cancer Inst . 2010; 23: 1746–1747

Alberg AJ, Gordon GB, Hoffman SC et al. Serum dehydroepiandrosterone and dehydroepiandrosterone sulfate and the subsequent risk of developing colon cancer. Cancer Epidemiol Biomarkers Prev. 2000; 9:517–521

Slattery ML, Sweeney C, Murtaugh M et al. Associations between ER alpha, ER beta, and AR genotypes and colon and rectal cancer. Cancer Epidemiol Biomarkers Prev.2005 ; 14:2936–2942

Eden A, Gaudet F, Waghmare A et al. Chromosomal instability and tumors promoted by DNA hy-pomethylation. Science . 2003; 300: 455

Draviam VM, Xie S, Sorger PK et al. Chromosome segregation and genomic stability. Curr Opin Genetics Develop. 2004; 14: 120–125

Lengauer C, Kinzler KW, Vogelstein B et al. Genetic instabilities in human cancers. Nature. 1998; 396:643–649.

Ribas M, Masramon L, Aiza G et al. The structural nature of chromosomal instability in colon cancer cells. FASEB J . 2003; 17:289–291

Camps J, Ponsa I, Ribas M et al. Comprehensive measurement of chromosomal instability in cancer cells: combination of fluorescence in situ hybridization and cytokinesis-block micronucleus assay. FASEB J. 2005; 19:828–830

Bardi G, Sukhikh T, Pandis N et al. Karyotypic characterization of colorectal adenocarcinomas. Genes Chromosomes Cancer. 1995; 12: 97–109

Muleris M, Dutrillaux AM, Olschwang S et al. Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients. Genes Chromosomes Cancer. 1995; 14:223–226

Iacopetta B .TP53 mutation in colorectal cancer. Hum Mutat. 2003; 21: 271-276

Lindblom A . Different mechanisms in the tumorigenesis of proximal and distal colon cancers. Curr Opin Oncol. 2001; 13:63-69

Solomon E, Borrow J, Goodard AD et al. Chromosome aberrations and cancer. Science. 1991 ; 254:1153-1160

Nakao K, Shibusawa M, Ishihara A et al. Genetic changes in colorectal carcinoma tumors with liver metastases analyzed by comparative genomic hybridization and DNA ploidy. Cancer. 2001; 91: 721-726

Knosel T, Schluns K, Stein U et al. Chromosomal alterations during lymphatic and liver metastasis formation of colorectal cancer. Neoplasia. 2004; 6: 23–28

Douglas EJ, Fiegler H, Rowan A et al. Array comparative genomic hybridi- zation analysis of colorectal cancer cell lines and primary carcinomas. Cancer Res. 2004; 64: 4817-482.

Anderson GR, Brenner BM, Swede H et al. Intrachromosomal genomic instability in human sporadic CRC measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR. Cancer Res. 2001; 61: 8274-8283

Cytogenetic Screening in Colorectal Cancer Patients of Tamil Nadu Population

Authors

Keywords:

Abstract

Downloads

References

Published

How to Cite

Issue

Section

Information