Healing potential of a polyherbal ointment on experimentally created incision, excision and diabetic excision wound models

Abstract

Wound is the interruption of the continuity in tissue resulting from the opening or break of the skin. Wound healing is an integrated cellular and biochemical process of restoring normal structure and functions of damaged tissue. In the present study an attempt was made to investigate the wound healing potential of a polyherbal ointment comprising of aqueous extract of Calophyllum inophyllum Linn, Albizia amara Roxb and Couroupita guianensis Aubl on incision wounds, excision wounds and diabetic excision wounds in albino rats. Animals weighing 150- 200g were divided into twelve groups each comprising of 6 rats each. Group I,V and IX served as incision, excision and diabetic excision wounded control respectively and Group II,III,VI,VII,X and XI served as rats treated with polyherbal ointment at two different doses (10% and 20%) of polyherbal ointment applied topically for 15days, Group IV and VIII served as incision and excision wounded animals treated with reference  ointment povidone and Group XII served as diabetic wounded animals treated with reference ointment silverex. The healing of the wound was assessed by the rate of wound contraction, tensile strength, hydroxy proline and hexosamine. The results suggested the potency of polyherbal ointment in the management of wound healing.