Screening Of Phytochemical And Glucose Absorption Inhibitory Potential Of Vigna radiata (L.) R. Wilczek

Abstract

Diabetes mellitus is a common and widespread disease affecting the citizens of both developing and developed countries. It is estimated that 25 % of the world population is affected by this disease. It is characterized by group of metabolic disorders. The deficiency or insensitivity of insulin causes glucose to accumulate in the blood, leading to various complications. The inhibition of carbohydrate hydrolyzing enzymes such as ? – amylase and ? – glucosidase can also be an important strategy to lower postprandial blood glucose levels. Therefore, it is the need of time to identify and explore the drugs from natural sources without side effects. For this present study a common plant with high nutritive value and fiber content Vigna radiata(L.) R. Wilczek. belongs to the family Fabaceae was selected and evaluated for its antidiabetic activity. Preliminary phytochemical constituents of plant were analyzed and showed the presence of sterol, tannin, flavonoid, coumarin, quinine, alkaloid, glycosides, sugar and phenols. In vitro evidence of antidiabetic potential was assessed by assaying the inhibition of ? – amylase and ? – glucosidase enzyme and the result was exhibited in a concentration dependent manner.