Evaluation of antihepatotoxic effect of Avicennia marina against alco-hol-induced liver injury
Keywords:
Ethanol, antihepatotoxic effect, A.marinaAbstract
This study aims to evaluate the antihepatotoxic effect of Avicennia marina against ethanol induced hepatotoxic rats. Qualitative phytochemical analysis was carried out in alcoholic extract of leaves of A.marina. The hepatoprotective effect A.marina was investigated against ethanol - induced hepatotoxic (group-III) rats and the activity of A.marina was compared with standard drug (Silymarin) treated (Group-IV) rats. Ethanol was used as hepatotoxic inducer for all experimental rats except for normal control (Group-I) rats and ethanol alone was given for disease control (Group-II) rats. Liver marker enzymes in serum (ALT, ALP, AST, GGT), Bilirubin, Protein and histopathological analysis were carried out. Ethanol treatment elevated levels of liver enzymes, decreased protein and histological damage in hepatocytes. However, treatment with A.marina significantly reversed the above changes compared with ethanol-challenged rats and was comparable with silymarin treated rats. The results clearly demonstrate that A.marina possesses promising antihepatotoxic effect and hence suggests its use as a potential therapeutic agent for protection from ethanol overdose.
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