Screening of potential antifungal compounds for uropathogens isolated from traditional Indian Medicinal plant of Carica papaya: In silico study
Keywords:
Urinary Tract Infections, Candidiasis, Molecular docking studiesAbstract
Urinary tract infections are one the most tedious infection and painful in India. The insufficient knowledge and misdiagnosis lead to the results of indiscriminate use in antibiotics which develop resistance. Fungal diseases are the most dangerous since the patterns of the infections varies person to person. Fungal spores in dermis can leads to severe infection and develop scars in moist and damp area. Herbal drugs and naturopathy makes sense now a day and found reliable for such infections, resistance in synthetic drugs are higher as compared to herbal ones. This research work used various active compounds selected from plant leaves of Carica papaya exhibiting antifungal activity. Molecular docking studies were performed. Selected compounds were validated and confirmed for drug design using ADME analysis virtually. A good reliable binding affinity was found among the compounds and fungal targets from Aspergillus and Candida selected on the base of virulence factors.
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