Degradation Study of Dapagliflozin in API by Spectro-scopic Method

Authors

  • Dr.(Mrs.)M.D. Game Department of Pharmaceutical Quality Assurance, Vidayabharti College of Pharmacy, C. K. Naidu Road, Sant Gadge Baba Amravati University, 444602, Maharashtra, India
  • Naglaxmi Bopudi Department of Pharmaceutical Quality Assurance, Vidayabharti College of Pharmacy, C. K. Naidu Road, Sant Gadge Baba Amravati University, 444602, Maharashtra, India

Keywords:

Dapagliflozin, UV- Spectroscopy, API, International Conference on Harmonization

Abstract

A simple, sensitive, precise, accurate, economic and rapid  visible spectroscopic method has been developed for estimation of dapagliflozin in API.Dapagliflozin was subjected to different stress conditions as per ICH guideline Q1A (R2). A stability- indicating UV Spectroscopic method has been developed for analysis of the drug in the presence of the degradation products. Degradation of Dapagliflozin was studied in acid, alkaline, hydrogen peroxide, photolytic, thermal and neutral conditions. The amount of degraded drug was calculated by taking absorbance at 272 nm.The drug was found to be more liable to decompositions in acidic,alkaline,oxidative , neutral medium than in photolytic and thermal conditions.

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References

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Published

2018-02-14
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How to Cite

Dr.(Mrs.)M.D. Game, and Naglaxmi Bopudi. “Degradation Study of Dapagliflozin in API by Spectro-Scopic Method”. International Journal of Pharmaceutics and Drug Analysis, vol. 6, no. 2, Feb. 2018, pp. 84-88, https://ijpda.org/index.php/journal/article/view/330.

Issue

Volume-6, Issue-2, February-2018

Section

Research Articles
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