Pharmacological Evaluation Of Anti-Depressant Activity Of Linum Usitatissimum In Mice Model
Keywords:
Linum usitatissimum, anti-depressant activityAbstract
Objective: The present study was designed to investigate the anti-depressant activity of the Linum usitatissimum.
Methods: Anti-depressant activity is evaluated by forced swim test, tail suspension test and open field test. Healthy albino mice (6-7 week old) weighing 20-40 grams were used. Potency of the test sample was compared with the standard fluoxetine drug.
Results: Results showed that the administration of the Linum usitatissimum produced adiminution of immobility time in mice exposed to the both forced swimming and tail suspension tests. In the present study, Linum usitatissimum (100mg/kg) administered to mice, produced significant anti-depressant like effect in both TST and FST and efficacy was found to be comparable to fluoxetine (20 mg/kg, ip).
Conclusion: Further studies would be necessary to evaluate the contribution of Linum usitatissimum for the observed anti-depressant activity as it still remains to be determined for the side effects.
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References
SK Chaurasia, DG Kane, LS Chaudhari. A comparative study of Linum usitatissimum vs a combination of diazepam and atropine for premedication in orthopaedic patients. J Post Graduate Medicine, 1999; 45(3):74-8.
Jae Hee Woo,Han Ji, Baik HJ and Lee H. Effects of Linum usitatissimum on the activity of the rat glutamate transport EAAT3 Expressed in Xenopus oocytes. Korean J Anesthesiol, 2012; 62(3):266-271.
Fabienne Masse, Hascoet M, Bourin M, ?2-Adrenergic agonists antagonize the anxolytic like effect of anti depressants in the four plate test in mice. Behavioural brain research, 2005; (164): 17-28.
Umadevi.P, Murugan.S, Jennifer Suganthi, Subakanmani S. Evaluation of antidepressant like activity of cucurbita pepo seed extracts in rats. IJCPR, Vol 3, Jan 2011.
R.Naga Kishore*1, N.Anjaneyulu1, M.Naga ganesh1, N.Sravya1, G.Abhinayani1, and C.Pratyusha1: Evaluation Of Antidepressant Activity Of Tramadolhydrochloride In Mice Model: Wjpps: Volume 1, Issue 4, 1384-1391.
Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl.), 1988; 94:147-30.
Mst. Hajerakhatun, Md.Rafikul Islam, Al Mamun, Laizuman Nahar, Luthfunnesa, Md. Anwar Ul Aslam. In vivo evaluation of CNS Depressant and Antinociceptive activities of Methanol extract of hibiscus sabdariffa fruits.JASR, 2011: 7(6).
R. Kishore*1, R. Sivakumar, N.Anjaneyulu1, M. Naga ganesh1, N.Sravya1, G.Abhinayani1 and M. Muralidhar Reddy1: Pharmacological Evaluation Of Antidepressant Activity Of Clonidine In Mice Model- Int J Pharm Pharm Sci, Vol 4,supply 1, 146-148.
Andrew Holmes, Rebecca J Yang, Dennis L Murphy, and Jacqueline N Crawley. Evaluation of antidepressant-related Bhavioural responses in mice lacking the serotonin transporter. Neuropsychopharmacology. 2001;27:914-923.
Malinge M, Bourin M, Colombel MC, Larousse C. Additive effects of Linum usitatissimum and Anti depressant drugs in the mouse Forced swimming test. Psychopharmacology, (1988); 96:104-109.
R.Naga kishore*, N.Anjaneyulu, M.Naga ganesh, N.Sravya; Evaluation Of Anxiolytic Activity Of Ethanolic Extract Of Foeniculum vulgare In Mice Model: Int J Pharm Pharm Sci, Vol 4, Issue 3, 584-586.
Kvavadze E, Bar-Yosef O, Belfer-Cohen A, Boaretto E, Jakeli N, Matskevich Z, Meshveliani T. (2009).30,000-Year-Old Wild Flax Fibers. Science, 325(5946):1359. doi:10.1126/science.1175404 PMID19745144 Supporting Online Material.
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