FORMULATION AND EVALUATION OF TRANS-DERMAL PATCH OF PROPRANOLOL HYDROCHLO-RIDE

Abstract

The purpose of this research was to develop a matrix type transdermal patch containing Propranolol hydrochloride and combination of two hydrophobic Polymers Eudragit L-100 and Eudragit S-100 by Solvent Evaporation technique.Combination of two Plasticizers Glycerine and Dibutyl phthalate were used and their effect on drug release was studied by changing their concentration in each batch.Methanol and Dichloromethane solvent system was used in which methanol acts as a penetration enhancer.Since oral bioavailibity of Propranolol Hydrochloride is poor due to high first pass metabolism transdermal patch is formed with the objective to get sustained release drug action with good bioavailibity.The Physicochemical compatibility of the drug and polymers suggested by infrared spectroscopy suggested absence of any incompatibility.Formulated transdermal films were physically evaluated for thickness, weight variation, drug content, moisture and folding endurance. All prepared formulation indicated good physical stability.Invitro drug release studies were performed by using Franz diffusion cells and cellophane membrane.Sustained release drug action was achieved in optimized batches.The Drug irritancy study show that there was no any noticeable sign of erythma or oedema on rabbit skin throughout the period of 48 hrs.