FORMULATION AND EVALUATION OF FAST DIS-INTEGRATING TABLETS OF SERTRALINE HCL BY USING NATURAL SUPER DISINTEGRANTS

Abstract

The speed of onset of action of antidepressant is clinically important for several reasons. Objective of this research was to formulate fast disintegrating tablets of sertraline hydrochloride by using natural superdisintegrants so that it will minimize time of onset of action and also become economic. Direct compression method is use to prepare fast disintegrating tablets. Paper describes impact of different concentration of natural superdisintegrants like gelatinized starch, treated agar on various parameters of fast disintegrating tablets of sertraline Hcl. All formulation were evaluated for various parameters such as hardness, friability, drug content, wetting time, dissolution study, disintegration test. An optimized formulation (GS-6) was found to have good hardness of 3.10 kg/cm², disintegration time of 22.37 second and dissolution of 95 % in 12 min.The conclusion is results obtained clearly indicate that optimized batch GS-6 having remarkable increase in disintegrating and dissolution time for the treatment of depression.