SIMULTANEOUS SPECTROPHOTOMETRIC ESTI-MATION OF CAMYLOFIN DIHYDROCHLORIDE AND DICLOFENAC POTASSIUM IN TABLET DOS-AGE FORM

Mr. Sujit Patil; Mr. H. D. Patil; Prof. R. P. Zope; Mr. Sachin S. Rane; Prof. (Dr.) Rajesh Y. Chaudhari; Prof. (Dr.) Vijay R. Patil

Authors

Mr. Sujit Patil Department of Pharmaceutical Chemistry, T.V.E.S.’s Hon. L. M. C. College of Pharmacy, Faizpur- 425 503, Dist-Jalgoan, (M.S.), India
Mr. H. D. Patil Department of Pharmaceutical Chemistry, T.V.E.S.’s Hon. L. M. C. College of Pharmacy, Faizpur- 425 503, Dist-Jalgoan, (M.S.), India.
Prof. R. P. Zope Department of Physics, Dhanaji Nana Mahavidyalaya, Faizpur
Mr. Sachin S. Rane Department of Pharmaceutical Chemistry, T.V.E.S.’s Hon. L. M. C. College of Pharmacy, Faizpur- 425 503, Dist-Jalgoan, (M.S.), India.
Prof. (Dr.) Rajesh Y. Chaudhari Department of Pharmaceutical Chemistry, T.V.E.S.’s Hon. L. M. C. College of Pharmacy, Faizpur- 425 503, Dist-Jalgoan, (M.S.), India
Prof. (Dr.) Vijay R. Patil Department of Pharmaceutical Chemistry, T.V.E.S.’s Hon. L. M. C. College of Pharmacy, Faizpur- 425 503, Dist-Jalgoan, (M.S.), India

Keywords:

Camylofin Dihydrochloride, Diclofenac Potassium, Validation, Simultaneous equation method

Abstract

The accurate, precise, sensitive and economical spectrophotometric method was developed and validated for simultaneous estimation of Camylofin Dihydrochloride and Diclofenac Potassium tablet dosage form. The method employed for UV estimation was simultaneous equation method. The method employs 248 nm as ?1 and 280 nm as ?2 for formation of equations. Camylofin Dihydrochloride and Diclofenac Potassium obeys Beer’s law in the concentration range 5-80 ?g/mL (r²=0.998) and 5-80 ?g/mL (r²=0.997). The mean recovery for Camylofin Dihydrochloride and Diclofenac Potassium, were found to be 99.652 ±0.2129% and 99.80 ±0.0.00307% respectively. The developed method were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. Thus the proposed methods were successfully applied for simultaneous determination of Camylofin Dihydrochloride and Diclofenac Potassium, routine analytical work.

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SIMULTANEOUS SPECTROPHOTOMETRIC ESTI-MATION OF CAMYLOFIN DIHYDROCHLORIDE AND DICLOFENAC POTASSIUM IN TABLET DOS-AGE FORM

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