Design and Development of a Gastro Retentive Tablet of Venlafaxine Hydrochloride by Wet Granulation Method.
Keywords:
Venlafaxine Hydrochloride, HPMC, Wet granulation, Floating tabletsAbstract
The present investigation describes the design and development of Gastro retentive system of Venlafaxine Hydrochloride. Floating tablets containing Venlafaxine Hydrochloride were prepared by wet granulation technique using varying concentrations of polymers with sodiumbicarbonate.It was found that gastro retention time of Venlafaxine Hydrochloride can be increased by formulating it in a floating dosage form using optimum amount of HPMC, sodium bicarbonate and citric acid. The floating tablets were evaluated for uniformity of weight, hardness, friability, drug content, invitro buoyancy and dissolution studies. The produced floating tablets exhibited good floating time and controlled drug release over a period of 8 hrs. It was concluded that floating tablet with good flow property and controlled release property can be obtained by optimizing amount of HPMC, sodium bicarbonate and citric acid. Among these formulations of Venlafaxine HCL,F2 showed maximum release and proved to be best.
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