MAGNETICALLY TARGETTED DRUG DELIVERY OF THE ANTICANCER DRUGS - CLINICAL PERSPECTIVE

B.R.KIRUPAKAR; DR.B.A.VISHWANATH, M.; R.SHWETHA; M.G.RAGHU

Authors

B.R.KIRUPAKAR Department Of Pharmaceutics, Aditya Bangalore Institute Of Pharmaceutical Education And Research
DR.B.A.VISHWANATH, M. Department Of Pharmaceutics, Aditya Bangalore Institute Of Pharmaceutical Education And Research
R.SHWETHA Department Of Pharmaceutics, Aditya Bangalore Institute Of Pharmaceutical Education And Research
M.G.RAGHU Department Of Pharmaceutics, Aditya Bangalore Institute Of Pharmaceutical Education And Research

Keywords:

Magnetic targeted drug delivery, Cancer drug, Preclinical and clinical study

Abstract

Last several decades controlled drug delivery technology has advanced significantly, leading to the development of various clinical formulations improving patient compliance. Targeted drug delivery to solid tumors still needs improvement to reach next level of clinical relevance. Overcoming the challenges involves understanding of drug transport to a target site after intravenous administration, target disease issues and body’s response. Targeted drug delivery refers to drug accumulation within target zone that is independent of method and route of administration. Targeted drug delivery require to retain, evade, target and release the drug loaded in the carrier. Targeted drug delivery system is classified as systemic targeting and intracellular targeting. Systemic targeting is further classified into ligand receptor mediated and locally activated drug delivery. Local activation is by self triggered and external triggered such as light, temperature, magnetic field and ultrasound. Magnetic drug delivery hold future promises for the cancer treatment drugs.