DEVELOPMENT AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM OF DILTIAZEM HYDROCHLORIDE

Abstract

The main aim of the present work was to develop and evaluate Diltiazem hydrochloride press coated pulsatile tablets which
releases the total amount of drug at early morning to tackle the difficulties that occur at cardiac diseases in morning such as
angina attack in morning, hypertension, heart attacks etc. prevent hypertension in patients. These systems are designed
according to the circadian rhythm of the body, and the drug formulation release drug rapidly and completely as a pulse after
a lag time. PDDS (Pulsatile drug delivery system) system employed for treating diseases which show their intense influence
at early morning, This press-coated Pulsatile tablets containing Diltiazem hydrochloride in the inner core was formulated
with different superdisintegrants fan outer barrier layer by HPMC K4M / HPMC K15M / HPMC K100 / Sodium alginate.
The inner core tablet was prepared by the direct compression method and outer barrier layer was applied by press coating
technique. The effect of polymer on the lag time of drug release was investigated. Prepared Press Coated Tablets was
evaluated for all physical tests. Among all the polymers HPMC K100 showed best lag time for a period of 6 hours and the
drug release was prolonged for a period of 8 hours. Compatibility studies carried out by FTIR and DSC studies revealed that
all the excipients and polymers were compatible with drug.