DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROMETRIC METHOD FOR DETERMINATION OF NICOTINE IN GUM TABLET

PATEL JIGNESH V; PATEL DIPTI B.

DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROMETRIC METHOD FOR DETERMINATION OF NICOTINE IN GUM TABLET

Authors

PATEL JIGNESH V Department of Pharmaceutical Quality Assurance, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Kherva – 382711, Mehsana, Gujarat, India.
PATEL DIPTI B. Department of Pharmaceutical Quality Assurance, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Kherva – 382711, Mehsana, Gujarat, India.

Keywords:

Nicotine, Folin-Ciocalteu, Chromogen, Spectrophotometric

Abstract

A simple, sensitive, accurate and rapid Spectrophotometric method has been developed for the estimation of nicotine
using Folin-Ciocalteu reagent in presence of 20% sodium carbonate solution. The blue color chromogen formed is
measured at wavelength of maximum absorption 760 nm, respectively against reagent blank. The chromogen obeyed
linearity over 3-14 ?g/ml for nicotine. The results of analysis have been validated statistically and by recovery studies.

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Published

2014-02-11

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How to Cite

PATEL JIGNESH V, and PATEL DIPTI B. “DEVELOPMENT AND VALIDATION OF VISIBLE SPECTROMETRIC METHOD FOR DETERMINATION OF NICOTINE IN GUM TABLET”. International Journal of Pharmaceutics and Drug Analysis, vol. 2, no. 2, Feb. 2014, pp. 100-5, https://ijpda.org/index.php/journal/article/view/16.