PAMAM Dendrimers mediated solubility enhancement of poorly soluble drugs: a concise review

Surya Prakash Gautam; Arun Kumar Gupta; Shahid Ud Din Wani; Neelesh Malviya; Tapsya Gautam; Anil Kumar Sharma

Authors

Surya Prakash Gautam Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore
Arun Kumar Gupta Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore
Shahid Ud Din Wani Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore Smriti College of Pharmaceutical Education, Indore
Neelesh Malviya Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore Smriti College of Pharmaceutical Education, Indore
Tapsya Gautam Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore Smriti College of Pharmaceutical Education, Indore
Anil Kumar Sharma Department of Pharmaceutics, CT institute of Pharmaceutical Sciences, Shahpur, Jalandhar. Department of pharmaceutical chemistry, RKDF, Indore Smriti College of Pharmaceutical Education, Indore

Keywords:

Solubility, Dendrimers, bioavailability

Abstract

High solubility, high permeability and good stability are basic prerequisites for achieving the bioavailability and hence
therapeutic effectiveness. Newly developed drugs having poor solubility are rejected or exhibit suboptimal performance.
Poor solubility of new chemical entities discovered or already in the market limits their use in formulation development.
Poor solubility being a major obstacle in all checkpoints in drug discovery pipeline. Plethora of techniques/methods are
used for the improvement of the solubility of poorly water-soluble drugs include micronization, chemical modification, pH
adjustment, solid dispersion, complexation, cosolvency, micellar solubilization, hydrotropy etc. Dendrimers a nanocarrier
shows tremendous Solublization potential. These nonmaterial’s have unique property to encapsulate the drug inside as well
as binding on surface by electrostatic interaction. The dendrimers is hypothesized to have the drug in their internal cavities
which are shielded by exterior groups. Various researchers have explored the Solublization potential of dendrimers using
poorly soluble drugs to provide the proof of concept. The results, patents and dendrimers based marketed preparations
revealed the efficacy of dendrimers for enhancement of solubility.