AN EXHAUSTIVE DETAIL OFTRANSDERMAL DRUG DELIVERY

Abstract

Transdermal drug delivery (TDD) is known to offer many advantages over the oral and injectable routes for systemic drug
delivery. However, the skin is a complex and dynamic organ with marked barrier function, which results in limitations and
variations in the amount and nature of drugs that can be delivered across the skin and into the bloodstream. Thus a
continual search for ways to optimize the permeation of drugs across the skin exists, in an attempt to enhance delivery and
improve patient compliance. Various type of transdermal patches are used that delivered the specific dose of medication
directly into the blood stream. The review article covers a brief outline of the transdermal drug delivery system, advantage
over conventional drug delivery system, influential factors in site-to-site TDDs variation, function and layers of the
skin,fundamentals of skin permeation, fundamentals of skin permeation, approaches used in the development of
transdermal drug delivery system, enhancement techniques, evaluation parameters of nanoparticle loaded patch.