Influence of Dielectric constant on Protonation Equilibria of Glutathione in aqueous solutions of propylene glycol and acetonitrile

Simhadri NVV; Bhaskara Rao K; Vijaya Kumar N; Siva Rao T; Nageswara Rao G

Influence of Dielectric constant on Protonation Equilibria of Glutathione in aqueous solutions of propylene glycol and acetonitrile

Authors

Simhadri NVV School of Chemistry, Andhra University, Visakhapatnam-530003, India.
Bhaskara Rao K School of Chemistry, Andhra University, Visakhapatnam-530003, India.
Vijaya Kumar N School of Chemistry, Andhra University,Visakhapatnam-530003, India
Siva Rao T School of Chemistry, Andhra University,Visakhapatnam-530003, India
Nageswara Rao G School of Chemistry, Andhra University,Visakhapatnam-530003, India

Keywords:

Protonation constants, glutathione, propylene glycol, acetonitrile, MINIQUAD75

Abstract

The protonation constants of glutathione have been determined pH metrically in 0.0-60.0% v/v propylene glycol- and
acetonitrile- water mixtures maintaining an ionic strength of 0.16 mol L-1 at 303.0 K. The protonation constants have been
calculated with the computer program MINIQUAD75 and the best fit chemical models are selected based on statistical
parameters. Linear variation of step-wise protonation constants with reciprocal of dielectric constant of the solvent mixture
has been attributed to the dominance of electrostatic forces.

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Published

2015-02-02

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How to Cite

Simhadri NVV, Bhaskara Rao K, Vijaya Kumar N, Siva Rao T, and Nageswara Rao G. “Influence of Dielectric Constant on Protonation Equilibria of Glutathione in Aqueous Solutions of Propylene Glycol and Acetonitrile”. International Journal of Pharmaceutics and Drug Analysis, vol. 3, no. 2, Feb. 2015, pp. 19-26, https://ijpda.org/index.php/journal/article/view/138.