DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF MOXONIDINE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM

Abstract

A rapid, precise, accurate and specific first-order derivative spectrophotometric method was developed for the
determination of moxonidine in pharmaceutical formulation. The technique was applied using 0.1M HCl as diluent. The
first-order derivative spectra were obtained and determination was made at 232 nm. The method showed good linearity in
the concentration range of 10-50 ?g/ml with correlation coefficient 0.999. The recovery ranged between 99.50 and 100.50
%. The proposed method will be suitable for the analysis of moxonidine in bulk and in marketed preparations. The results of
analysis have been validated statistically and by recovery studies.