Antioxidant and antidiarrhoeal activities of methanolic extract of Artocarpus heterophyllus seed

Abstract

The present study was designed to investigate antidiarrheal and antioxidant activities of the methanolic extract of
Artocarpus heterophyllus seed (ATS). Total phenolic content, total antioxidant activity, scavenging of 1, 1-diphenyl-2-
picrylhydrazyl (DPPH) radical were used to evaluate antioxidant potential of ATS. In DPPH method, ATS showed
moderate antioxidant potentiality in a dose dependent manner with the IC50 value of 116.04 ?g/ml . The phenolic content of
methanol extract of ATS was 437± .006 mg of GAE / gm of dried extract .Total antioxidant capacity of ATS was found to
be 170.75± .001 mg/gm equivalent of ascorbic acid .The extract was studied for antidiarrheal property using castor oil in
mice. At the doses of 200 and 400 mg/kg body weight, the extract reduced the frequency and severity of diarrhea in test
animals throughout the study period .Altogether, these results suggest that the ATS could be used as a potential
antidiarrhoeal agent along with its antioxidant potentiality.