INSILICO RELATIVE COMPOUND TOXICITY OF PEDILANTHUS TITHYMALOIDES AGAINST ORAL RAT

Abstract

Pedilanthus tithymaloides, a common plant of the tropical countries, is widely used in ethno medicine. However, the
toxicity profile of the plant is not much studied. The present study focuses on the prediction of toxicity in Oral rats of the
chemicals detected through GC-MS. The compounds of Pedilanthus tithymaloides were subjected to toxicity analysis using
Toxicity Estimation Software Tool (T.E.S.T). This in-silico QSAR model was used to predict the LD50and the predicted
values of the compounds 10-Octadecenoic acid, methyl ester; Cyclopropane butanoic acid, 2-[[2-[[2-[(2-pentyl cyclo
propyl) methyl] cyclopropyl] methyl] cyclo propyl] methyl]-, methyl ester; Pentadecanoic acid, 14-methyl-, methyl ester;
(4,4-Diphenyl-butyl)-(3-phenyl-piperidin-4-yl-)-amine and Rescinnamine against Oral rat are 15263.11, 4111.09, 16739.33,
754.43 and 603.44mg/kg respectively, concluding that these compounds were less or non-toxic to oral consumption.