FORMULATION AND EVALUATION OF LOSARTAN HYDROGEL BEADS

Abstract

Losartan is a potent calcium channel blocker used in the treatment of hypertension. Losartan has shorter half life of 2 hours.
The objective of study is to formulate and evaluate the alginate hydrogel beads of Losartan as a model drug by ionic
geleation method using cacl2 as cross linking agent. the hydrogel beads were formulated using sodium alginate, HPMC and
Carbopol as polymers. The drug is deliver at controlled/sustained manner into GIT consequently to the systemic circulation.
the prepared hydrogels were evaluated for particle size, flow properties, entrapment efficiency, swelling index, %yield and
in-vitro drug release studies.From the five different formulations, we found that F5 has shown best performance and % drug
release and when we compare to other formulations.