MUCOADHESION: A NOVELISTIC PLATFORM FOR DRUG DELIVERY SYSTEM

Abstract

The process of mucoadhesion involving a polymeric drug delivery system is a complex one that includes processes such as
wetting, adsorption and interpenetration of polymer chains. The success and degree of mucoadhesion bonding is influenced
by various polymer-based properties such as the degree of cross-linking, chain length and the presence of various functional
groupings. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing
a controlled rate of drug release for better therapeutic results. These systems remain in close contact with the absorption
tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and
systemic effects. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. Oral
mucoadhesivemicrocarriers were having potentiality for controlling and extending release profile so as to improve
performance and patient compliance. The aim of this study was to review the mechanisms and theories involved in
mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery system.