International Journal of Pharmaceutics and Drug Analysis

GREEN ANALYTICAL CHEMISTRY IN PHARMACEUTICAL METHOD DEVELOPMENT: SUSTAINABLE APPROACHES

Mon, 18 May 2026 00:00:00 -0400

Green Analytical Chemistry (GAC) has emerged as a sustainable approach in pharmaceutical method development, aiming to minimise environmental impact while maintaining analytical efficiency and reliability. Conventional analytical techniques often rely on toxic solvents, high energy consumption, and generate significant chemical waste, necessitating the adoption of greener alternatives. This review highlights the principles of GAC, including reduction of hazardous reagents, minimisation of solvent use, energy efficiency, waste management, and the use of renewable materials. The application of green solvents such as water, ethanol, supercritical CO?, ionic liquids, and deep eutectic solvents is discussed. Various green analytical techniques, including green HPLC, UPLC, SFC, spectroscopic methods, electroanalytical techniques, and microextraction approaches, are explored for sustainable pharmaceutical analysis. Additionally, green sample preparation methods and evaluation tools such as Analytical Eco-Scale, GAPI, and AGREE are emphasised for assessing method greenness. Despite significant advancements, challenges such as limited green alternatives, validation complexities, and cost constraints remain. The integration of green principles with modern analytical technologies is essential for achieving environmentally sustainable pharmaceutical practices.

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INFLUENCE OF POLYPHARMACY MANAGEMENT ON CARDIOVASCULAR OUTCOMES IN PTCA PATIENTS WITH LIFESTYLE AWARENESS: A PROSPECTIVE OBSERVATIONAL STUDY COMPARING PATIENTS WITH AND WITHOUT POLYPHARMACY INTERVENTIONS

L Meena Kumari, I Sweety, Bhaskar Muchahary, A.Lakshmikar, P Pravallika — Mon, 18 May 2026 00:00:00 -0400

This prospective observational study evaluated the impact of polypharmacy management and lifestyle awareness on cardiovascular outcomes in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). Conducted over six months in a secondary care hospital, 130 patients with coronary artery disease (CAD) were assessed using clinical data, medication records, and lifestyle modification scores. Interventions included medication review, optimization, dose adjustments, and patient counseling by clinical pharmacists, alongside lifestyle education. The majority of patients were males aged 51–60 years, with high prevalence of comorbidities such as hypertension and diabetes. Statins and dual antiplatelet therapy were the most frequently prescribed drugs. Patients receiving polypharmacy interventions demonstrated improved medication adherence, better awareness, and reduced rehospitalization rates compared to those without interventions. The findings highlight the critical role of structured pharmaceutical care and lifestyle modification in enhancing long-term cardiovascular outcomes and quality of life in post-PTCA patients, emphasizing the need for integrated, patient-centered management strategies.

ANALYTICAL STANDARDIZATION OF GANDHAGARASAYANAM- ASIDDHA POLYHERBO MINERAL FORMULATION

Pushpa P, Shankar S — Mon, 18 May 2026 00:00:00 -0400

Gandhaga Rasayanam is a Siddhadrug widely used in the treatment of skin diseases. There are multiple methods and various herbo-mineral combinations abundantin Siddha texts to prepare Gandhaga rasayanam. The scientific standardization of traditional preparations is essential to ensure their quality, safety and efficacy. The present study aims to evaluate the physiochemical parameters of Gandhaga rasayanam prepared by, as per the reference Anuboga Vaidya Navaneedham- part 6. It was then subjected to physiochemical and phytochemical evaluation,tests for microbial load, aflatoxins and pesticide residuesas per AYUSH guidelines. The formulation exhibited the presence of characteristic bioactive ingredients in HPTLC profiling and phytochemical evaluation. The safety of this drug is assessed by screening microbial load, identification of aflatoxins and detection of pesticide levels. Thus, the study provides scientific evidence supporting the quality, efficacy, and standardization of the formulation highlighting its potential for further clinical and pharmacological investigations.

INSTRUMENTAL ANALYSIS OF SIDDHA POLYHERBAL FORMULATION - SAARANAI MOOLI KUZHAMBU

Rajasankar V, S Shankar — Mon, 18 May 2026 00:00:00 -0400

Saaranai Mooli Kuzhambu (SMK) is a polyherbal formulation described in classical Siddha literature for Paandu Noi (Anemia). Standardizing Siddha polyherbal formulation is necessary to ensure the quality of medicines for their safe usage.The study aims to standardize the SMK by modern instrumental analytical techniques such as Scanning Electron Microscopy (SEM), Fourier Transform Infra-Red Spectroscopy (FTIR), and ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometry). The SMK had been prepared as per the reference text “Pathinen Siddharkal Vaithiya Sillaraik Kovai Part II” and screened for particle size, identification of functional groups, and detection of heavy metal contamination. SEM analysis was carried out at IIT-Madras, Chennai. The SEM analysis of the sample showed the presence of nano-and micro particles. The FT-IR spectroscopy and ICP-OES were performed at CCRAS, Chennai. FT-IR has revealed the presence of functional groups like alcohol, carbonyl, amines, and Ethers. ICP-OES indicated that heavy metals such as arsenic, cadmium, mercury, and lead are detected below the limit of quantification. This study shows how modern standardization methods can improve the reliability and acceptance of polyherbal formulations at the global level.The results show that SMK is preferably nontoxic when used at the recommended dose.