Simplified uv spectrophotometric analysis of abiraterone acetate in bulk and formulations

Authors

  • Ramakrishna .M Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • J.N.Suresh Kumar Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • Lakshmi Roshini.J Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • Sai Tejaswini.T Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • Jagadeesh.N Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • Jessie Snehita.K Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India
  • Siva Reddy.A Department of Pharmaceutical Analysis, Narasaraopeta Institute of Pharmaceutical Sciences, Kotappakonda road, Yallamanda, Narasaraopeta, Palnadu, Andhra Pradesh, India

DOI:

https://doi.org/10.47957/ijpda.v12i1.582

Keywords:

Abiraterone acetate, UV spectrophotometric method, solubility, ?max, linearity, LOD, LOQ, RSD

Abstract

Abiraterone acetate is an orally administered selective androgen biosynthesis inhibitor It is an irreversible inhibitor of cytochrome CYP17AThis enzyme is expressed in testicular, adrenal, and prostatic tumour tissues and is required for androgen biosynthesis.Abiraterone is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body.A Novel, simple, accurate, precise and reproducible UV spectrophotometric method has been developed and validated for estimation of Abiraterone acetate bulk and its formulations. After determining the solubility we had selected methanol as a solvent and Abiraterone acetate has absorbance at the wavelength of maximum ?max254nm. The drug was characterized by the melting point test. Proposed method was precise with RSD less than 2%. linearity test was approved within the range of 10-60µg/ml for with the correlation coefficient (R2) of 0.9991. Accuracy was 100.03%. LOD and LOQ were 0.006µg/ml and 0.018µg/ml respectively. The spike recovery of Abiraterone acetate in tablet was 99.88%.

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References

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Published

2024-04-14
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How to Cite

M, R., S. K. J.N, L. R. J, S. T. T, J. N, J. S. K, and S. R. A. “Simplified Uv Spectrophotometric Analysis of Abiraterone Acetate in Bulk and Formulations”. International Journal of Pharmaceutics and Drug Analysis, vol. 12, no. 1, Apr. 2024, pp. 37-42, doi:10.47957/ijpda.v12i1.582.

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