Preparation and Evaluation of Niosomal Gel Loaded With Combination of Isotretinion and Clindamycin
DOI:
https://doi.org/10.47957/ijpda.v12i1.577Keywords:
Niosomes, Isotretinion, Clindamycin, Carbopol gel, Acne, Ether injection methodAbstract
The objective of the present study was to formulate topical niosomal gel loaded with combination of Isotretinion and Clindamycin for the beneficial of acne patients, to provide sustained release effects, to prevent their side effects. First generation topicals retinoids (Isotretinion) and antibacterials (Clindamycin) target comedones, Propionibacterium acnes or inflammation. The combination of Isotretinion and Clindamycin is reported to treat almost all type of acne and have potential to increase both efficacies, patient adherence as compared to single agent treatment. Purpose of this study was to develop a stable formulation that allows progressive follicle penetration and increased efficacy. Preformulation studies such as melting point, FTIR spectroscopy, UV spectroscopy, solubility, partition coefficient (log P) were performed for both drugs. The niosomal combination of both drugs was incorporated into the carbopol gel. The pH and viscosity of gel was performed.
Downloads
References
Goyal G, Garg T, Malik B, Chauhan G, Rath G, Goyal AK. Development and characterization of niosomal gel for topical delivery of benzoyl peroxide. Drug delivery. 2015 Nov 17;22(8):1027-42.
Fetih G. Fluconazole-loaded niosomal gels as a topical ocular drug delivery system for corneal fungal infections. Journal of Drug Delivery Science and Technology. 2016 Oct 1;35:8-15.
Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta pharmaceutica sinica B. 2011 Dec 1;1(4):208-19.
Mishra V, Nayak P, Singh M, Sriram P, Suttee A. Niosomes: potential nanocarriers for drug delivery. International Journal of Pharmaceutical Quality Assurance. 2020;11(3):389-394.
Hao YM. Entrapment and release difference resulting from hydrogen bonding interactions in niosome. International journal of pharmaceutics. 2011 Jan 17;403(1-2):245-53.
Habib BA, Abdeltawab NF, Salah Ad-Din I. D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes. Drug Delivery. 2022 Dec 31;29(1):821-36.
Manconi M, Sinico C, Valenti D, Lai F, Fadda AM. Niosomes as carriers for tretinoin: III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin. International journal of pharmaceutics. 2006 Mar 27;311(1-2):11-9.
Budhiraja A, Dhingra G. (2015). Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug Deliv 22:723–30.
Khalil NY, Darwish IA, Al-Qahtani AA. Isotretinoin. Profiles Drug Subst Excip Relat Methodol. 2020;45:119–157.
Kaminska EC. Treatment of acne and acne-related scarring with fixed combination clindamycin phosphate and benzoyl peroxide gel (1.2%/3.75%) and tretinoin gel microsphere 0.06% in an Asian American transgender female. SAGE Open Medical Case Reports. 2020 Dec;8:2050313X20984038.
Greydanus DE, Azmeh R, Cabral MD, et al. Acne in the first three decades of life: an update of a disorder with profound implications for all decades of life. Dis Mon. 2021;67(4):101103.
Alam A, Mustafa G, Agrawal GP, Hashmi S, Khan RA, Alkhayl FF, Ullah Z, Ali MS, Elkirdasy AF, Khan S. A microemulsion-based gel of isotretinoin and erythromycin estolate for the management of acne. Journal of Drug Delivery Science and Technology. 2022 Mar 22:103277.
Tarekegn A, Joseph NM, Palani S, Zacharia A, Ayenew Z. Niosomes in targeted drug delivery: some recent advances. IJPSR. 2010;1(9):1-8.
Islam, M.T., Rodriguez-Hornedo, N., Ciotti, S. and Ackermann, C., 2004. Rheological characterization of topical carbomer gels neutralized to different pH. Pharmaceutical research, 21(7), pp.1192-1199.
Das MK, Ahmed AB. Formulation and ex vivo evaluation of rofecoxib gel for topical application. Acta Pol Pharm. 2007 Sep 1;64(5):461-7.
Bayindir ZS, Yuksel N. Characterization of niosomes prepared with various nonionic surfactants for paclitaxel oral delivery. Journal of pharmaceutical sciences. 2010 Apr 1;99(4):2049-60.
Azmin MN, Florence AT, Handjani?Vila RM, Stuart JF, Vanlerberghe G, Whittaker JS. The effect of non?ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. Journal of pharmacy and pharmacology. 1985 Apr;37(4):237-42.
Ramachandran R, Shanmughavel P. Preparation and characterization of biopolymeric nanoparticles used in drug delivery.
Bragagni M, Mennini N, Ghelardini C, Mura P. Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting. Journal of pharmacy & pharmaceutical sciences. 2012 Feb 10;15(1):184-96.
Saraogi GK, Tholiya S, Mishra Y, Mishra V, Albutti A, Nayak P, Tambuwala MM. Formulation Development and Evaluation of Pravastatin-Loaded Nanogel for Hyperlipidemia Management. Gels. 2022 Jan 28;8(2):81.
Phatak AA, Sonawane DC, Chaudhari PD. Preparation and evaluation of stable nonionic surfactant vesicular system for tramadol HCl. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2013;4(3):1268-77.
Mekkawy A, Fathy M, El-Shanawany S. Formulation and in vitro evaluation of fluconazole topical gels. British Journal of Pharmaceutical Research. 2013;3(3):293-313.
Bachhav YG, Patravale VB. Formulation of meloxicam gel for topical application: In vitro and in vivo evaluation. Acta pharmaceutica. 2010 Jun 1;60(2):153-63.
Published
How to Cite
Issue
Section
Copyright (c) 2024 Pardeep Kaur, Ritu Rani, Amar Pal Singh, Ajeet Pal Singh
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.