Advancement in gastro retentive floating tablet: an updated review

Vishal Rana; Ritu Rani; Rajesh Kumar; Ajeet Pal Singh; Amar Pal Singh

doi:10.47957/ijpda.v12i1.573

Authors

Vishal Rana Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
Ritu Rani Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
Rajesh Kumar Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
Ajeet Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
Amar Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.

DOI:

https://doi.org/10.47957/ijpda.v12i1.573

Keywords:

Gastroretentive, GRDDS, Gastric Retention, Gastro-Retentive Drug Delivery System

Abstract

The widespread use of oral dose forms in disease treatment may lead to inadequate pharmacokinetic properties due to rapid transit through the gastrointestinal tract. This makes it challenging to achieve therapeutic levels in situations where the medicine is barely soluble. Studies have been conducted to identify formulations that enhance these characteristics while extending stomach residence time, with gastro retentive controlled drug delivery systems being beneficial. This study evaluates recent developments in FDDS, focusing on how these systems function to make dosage forms float in stomach fluid for gradual release, better gastric retention, and improved bioavailability of oral medicine. It discusses the pharmaceutical importance of GRDDS, stomach physiology, and factors controlling gastric retention. The review also discusses the preparation of GRDDS, polymeric materials, dosage form evaluation, and comparisons between conventional and GRDDS. In this abstract, we will keep an eye on updated review on recent advancement in gastro retentive floating tablet.

Downloads

Download data is not yet available.

References

Singh BN and Kim. Floating drug delivery systems: an approach to controlled drug delivery via gastric retention. J. Control. Release.2000;63:235-239.

Patole, R., Chaware, B., Mohite, V., & Redasani, V. (2023). A Review for Gastro - Retentive Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 11(4), 79-94. https://doi.org/https://doi.org/10.22270/ajprd.v11i4.1291

Rouge N,Buri P,Doelker E.;Drug Absorption Sites in the Gastrointestinal Tract and Dosage Forms for Site Specific Delivery;IntJPharma.1996;136:117-139.

Streubel A, Siepmann J, Bodmeier R; Gastroretentive Drug Delivery System; Expert Opin DrugDelivery; 2006;3 (2):217-233.

Kothari Abhay kumar H, Jaimini Manish, Gastroretentive drug delivery system and its approaches:a review,International journal of pharmaceutical research and development,2013,4(12),7-18.

Rajora, A., & Nagpal, K. (2022). A Critical Review on Floating Tablets as a Tool for Achieving Better Gastric Retention. Critical reviews in therapeutic drug carrier systems, 39(1), 65–103. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2021038568

Tomar, A., Upadhyay, A., Gupta, S.K., & Kumar, S. (2019). An Overview on Gastroretentive Drug Delivery System: Current Approaches and Advancements. Current Research in Pharmaceutical Sciences.doi: 10.24092/CRPS.2019.090102

Tripathi, J., Thapa, P., Maharjan, R., & Jeong, S. H. (2019). Current State and Future Perspectives on Gastroretentive Drug Delivery Systems. Pharmaceutics, 11(4), 193. https://doi.org/10.3390/pharmaceutics11040193

Vinchurkar, K., Sainy, J., Khan, M. A., Mane, S., Mishra, D. K., & Dixit, P. (2022). Features and Facts of a Gastroretentive Drug Delivery System-A Review. Turkish journal of pharmaceutical sciences, 19(4), 476–487. https://doi.org/10.4274/tjps.galenos.2021.44959

Zanke, Ashwini & Gangurde, Hemant & Ghonge, Ananta & Chavan, Praful. (2022). Recent Advance in Gastroretantive Drug Delivery System (GRDDS). Asian Journal of Pharmaceutical Research(AJPRes.) page 143-149. DOI: 10.52711/2231-5691.2022.00022

Ali J, Arora S, Khar RK. Floating drug delivery System: A Review. AAPS Pharm Sci Tech. 2005; 06(03):E372-E390.

Streubel A, Siepmann J, Bodmeier R. Gastroretentive drug delivery system. Expert Opin Drug Deliv 2006; 3(2):217-233.

Garg R,Gupta GD.Progress in controlled gastroretentive delivery systems. Trop. J Pharm Res2008;7(3):1055-66.

S.J. Hwang, H Park and K Park, ?Gastric Retentive Drug Delivery Systems,?Critical Reviews in Therapeutic Drug Carrier Systems,15(3)(1998),pp.243-284.

Swetha S, Allena RT and Gowda DV: A comprehensive review on gastro retentive drug delivery systems. International Journal of Pharmaceutical and Biomedical Research 2012;3:1285-1293.

Hranath C., Junaid A.H.,Sree P.S. Advancing drug delivery: unveiling the potential of gastroretentive systems. International Journal of modern pharmaceutical research,IJMPR 2023,7(9),31-39.

Kawatra M, Jain U and Ramana J:Recent advances in floating microspheres as gastro-retentive drug delivery system:A review. International Journal of Recent Advances in Pharmaceutical Research2012;2:5-23.

Klausner EA, Lavy E, Friedman M, et al. Expandable gastroretentive dosage forms. J Control Release 2003;90:143–162.

Laulicht B,Tripathi A, Schlageter V, etal.Understanding gastric forces calculated from high-resolution pill tracking. Proc Natl Acad Sci USA 2010;107:8201–8206.

Talukder R, Fassihi R. Gastroretentive delivery systems: a mini review.Drug Dev Ind Pharm 2004;30:1019–1028.

Gutierrez-Rocca J, Omidian H, Shah K. Progresses in gastroretentive drug delivery systems.Bus Brief Pharmatech2003;15:3–6.

Anne Waugh and Allison Grant. The digestive system: Stomach-Functions of stomach. Ross ans Wilson anatomy and physiology in health and illness. Edited by Elsiver Publications. 2014; 12th Edition:301.

Clarke GM, Newton JM and Short MD. Gastrointestinal transit of pellets of differing size and density.International journal pharmaceutics.1993;100(13):81-92.

Pund, Aniket & Shendge, Raosaheb & Pote, Ajinkya. (2020). Current Approaches on Gastroretentive Drug Delivery systems. Journal of Drug Delivery and Therapeutics. 10. 139-146. 10.22270/jddt.v10i1.3803.

MoesAJ.Gastric retention system for oral drug delivery.Business briefing. Pharmatech.2003;157-159.

Prajapati VD, Jani GK, Khutliwala TA, Zala BS. Raft forming system an upcoming approach of gastroretentive drug delivery system. J Control Release2013;168:151-65.

Aboue latta SM, Aboelwafa AA, El-Gazayerly ON. Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug. Drug Deliv2018;25:1161-74.

Hampson FC, Jolliffe IG, Bakhtyari A, Taylor G, Sykes J, Johnstone LM, et al. Alginate-antacid combinations: Raft formation and gastric retention studies. Drug Dev Ind Pharm2010;36:614-23.

AbouYoussef NA,Kassem AA,El-Massik MA,Boraie NA.Development of gastroretentive metronidazole floating raft system for targeting Helicobacterpylori. Int J Pharm2015;486:297-305.

Rao BP, Kottan NA, Snehith VH and Ramesh C. Development of gastro retentive drug delivery system of Cephalexin by using factorial design.ARE Pharmaceutical.2009;50:8.

Sheth PR and Tossounian J. The hydrodyanamically balanced system.A novel drug delivery system for oral use.Drug delivery Indian Pharmaceutics.2010;3(1):819-833.

Sharma N, Agarwal D, Gupta M and Khinchi M: A comprehensive review on floating drug delivery system. International Journal of Research in Pharmaceutical and Biomedical sciences 2011;2:428-441.

Bhardwaj L, Sharma PK and Malviya R: A short review on gastroretentive formulations for stomach specific drug delivery: special emphasis on floating in-situ gel systems. African Journal of Basic and Applied Sciences 2011;3:300-312.

Pal, Rahul & Pandey, Prachi & Nogai, Lipi & Arushi, Arushi & Anand, Amit & Suthar, Pallavi & Keskar, Madhuri & Kumar, Vikash. (2023). the future perspectives and novel approach on gastro retentive drug delivery system (grdds) with currrent state. Journal of Population Therapeutics and Clinical Pharmacology. 30. 594-613. 10.53555/jptcp.v30i17.2852.

Klausner,E.A.,LavyE.,Friedman,M.,Hoffman,A.,(2003)Expandable gastroretentive dosage forms. J. Control. Release 90, 143–162.

Garg R., Gupta G.D. (2008) Progress in Controlled Gastroretentive Delivery Systems.Trop.J. Pharm. Res.,7 (3):1055-1066

Hoffman A.(1998) Pharmacodynamic aspects of sustained release preparation. Adv. Drug Deliv.Rev. 33:185-199.

Hoffman A., Stepensky D. (1999) Pharmacodynamic aspects of modes of drug administration for optimization of drug therapy.Crit. Rev.Ther. DrugcarrierSyst.16:571-639.

Streubel A, Siepmann J, Bodmeier R, Floating Microparticles Based on Low Density Foam Powder, Int. J. Pharm,2002,241,279-N292.

Streubel A, Siepmann J, Bodmeier R. Floating Matrix Tablets Based on Low Density Foam Powder, Effects of Formulation and Processing Parameters on Drug Release, Eur. J.Pharm.Sci,2003,18,37-45.

Gaba P, Gaba M, Garg R and Gupta GD, Floating Microspheres, AReview. Pharmainfo.Net,2008,6(5),121123.

Kale R, Rao BS,Sharm S,Ramanmurthy KV, Preparation and Evaluation of Floatable Drug Delivery System of KetorolacTromethamine, Int.J.Pharm,2001,64- 65.

Muthuamy K,Govindarajan G, Ravi TK, Preparation and Evaluation of Lansoprazole Floating Micropellets, Indian J. Pharm. Sci, 2005,67(1),75-79.

Streubel A, Siepmann J, Bodmeier R, Floating Microparticles Based onLowDensityFoam Powder,Int. J. Pharm,2002,241,279-292.

Chokshi R, Zia H, Hot Melt Extrusion Technique, A Review, Iranian JPharmRes,2004,3:3-16.

Kidokoro M,Sasaki K,Haramiishi Y,Matahira N, Effect of Crystallization Behaviour of Polyethylene Glycol 6000 on the Properties of Granule Prepared by Fluidized Hot Melt Granulation(FHMG), Chem Pharm Bull,2003,51(5):487–493.

Ghori MU, Grover LM, Asare-Addo K,Smith AM,Conway BR.Evaluating the swelling,erosion and compaction properties of cellulose ethers. Pharmaceutical Development and Technology. 2017;(2):183–97.

Zubedi SS, Mohammed S. Floating Tablets and itsPolymers. Journal of Drug Delivery and Therapeutics.2018;8(5-s):16–24.

Jafar M, Alghamdi HS, Khalid MS, Al-Hussain MJ, Alghamdi SA,Alahamad ZY,Almoumen AM.Enhanced analgesic activity and reduced gastric ulceration potential of ibuprofen sodium through a novel buoyant InSitu gelling system.Lat.Am.J.Pharm.2019,38:599–608.

Sharma D, Sharma A. Gastroretentive drug delivery system - a mini review. Asian Pacific Journal of HealthSciences.2014; (2):80–9.

Kim H, Lee CL, Lee S, et al. Mechanically robust gastroretentive drug-delivery systems capable of controlling dissolution behaviors of coground ? lapachone.Pharmaceutics.2019,11.

Hanif M, Abbas G. pH-responsive alginate-pectin polymeric rafts and their characterization.Adv Polym Technol.2018;37(5):1496–506. Available from: http://dx.doi.org/10.1002/adv.21808.

R. Varges P, M. Costa C, S. Fonseca B, F. Naccache M, de SouzaMendes P. Rheological characterization of carbopol® dispersions inwater and in water/glycerol solutions. Fluids [Internet]. 2019; 4(1):3.Availablefrom:http://dx.doi.org/10.3390/fluids4010003.

Panda M,Rao MEB,Patra CN,Panda J,Panigrahi KC,Patro G.Formulation and development of floating multiple-unit minitablets of Nimodipine without using a gas-generating agent: in vitro and in vivo characterization. Futur J Pharm Sci.2020;6(1). Available from: http://dx.doi.org/10.1186/s43094-020-0021-x.

Li Q, Guan X, Cui M, Zhu Z, Chen K, Wen H, et al. Preparation andinvestigation of novel gastro-floating tablets with 3D extrusionbasedprinting.IntJPharm[Internet].2018;535(1–2):325–32.Availablefrom:http://dx.doi.org/10.1016/j.ijpharm.2017.10.037.

Panda S, Sailada NS, Devi B, Pattnaik S, Maharana L. Design of floating drug delivery systems: An update on polymeric advancements with special reference from natural origin. Int. J. Pharm. Sci. Rev. Res.2016;39:125–132.

Yen MK, Jenkins PG, Davis SS, Combs GA, Improvement of Delivery Capabilities of Microparticle System susing Blend of Poly(D,L-Lactate Co-Glycoside) Poly (Ethylene Glycol), J ContRel, 1995, 37, 1-9.

Shimpi S, Chauhan B, Mahadik KR,Paradkar P,Preparation and Evaluation of Diltiazem Hydrochloride-Gelucire43/01 Floating Granules Prepared by Melt Granulation, AAPS Pharm sci tec,2004,5(3),Article43.

Chen J, Blevins WE, Park H, Park K, Gastric Retention Properties of Superporous Hydrogel Composites, J Con Rel, 2000,64,39-51.

Deshpande A A, Rhodes C T, Shah N H. Controlled release drug delivery system for prolonged gastric residence: an overview,? DrugDev.Ind.Pharm,22(6),1996,531- 539.

Desai S,Bolton S. A floating controlled release drug delivery system:in vitro-in vivo evaluation,PharmRes,10(9),1993,1321-1325.