Aquasomes: an updated review

Authors

  • Gurpreet Kumar Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
  • Ritu Rani Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
  • Ajeet Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.
  • Amar Pal Singh Department of Pharmaceutics, St. Soldier Institute of Pharmacy, lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar By Pass, Nh-1, Jalandhar -144011, Punjab, India.

DOI:

https://doi.org/10.47957/ijpda.v12i1.571

Keywords:

Aquasomes, formulation, Preparation methods, Application

Abstract

Aquasomes are circular particles that serve as nano particulate carrier systems, consisting of a solid phase nanocrystalline core coated in an oligomeric film. These three-layered self-assembled structures, ranging from 60 to 300 nanometers in size, allow direct or indirect absorption of biochemically active molecules. Aquasomes can be loaded with large amounts of agents through entropic, van der Waals, and ionic forces due to their size and active surface area. They display colloidal physical characteristics in an aqueous medium and are effective in distributing insulin, hemoglobin, serratiopeptidase, and poorly water-soluble medications.eramic nanoparticles, also known as aquasomes, are spherical particles that self-assemble into nanoparticulate carriers, resembling water bodies. These self-assembled structures are effective in the distribution of hemoglobin, insulin, and enzymes like serratiopeptidase. In this abstract, we will cover a review on Aquasomes.

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References

Rajak, Prakash & Islam, Rofiqul & Karmakar, Arka & Bhuyan, Biman. (2023). Aquasomal drug delivery system: A special emphasis on the formulation techniques and applications. Ars Pharmaceutica (Internet). 64. 359-375. 10.30827/ars.v64i4.28264.

Chaudhari M, Pandya D,Thakkar P,Soni A, Modi D.2013. Aquasomes: a novel drug delivery system.ChemInform.,44(38).

GirotraL,Bajaj R.2012. Emerging Trends And Recent Advances In Aquasomes: A Review.InventiRapid:PharmTech..

Rao S et al., Aquasomes: A Nanoparticulate Drug Carrier System . American Journal of PharmTech Research 2018. Page-29-35

Shahabade Gururaj S, Bhosale Ashok V,Mutha Swati S,Bhosale Nilesh R,Khade Prashant H.2009 An overview on nanocarrier technology-Aquasomes.Journal of Pharmacy Research, 2(7).

Wani S,Yerawar A.2011.Aquasomes:A novel nanocarrier for drug delivery. ChemInform.42(46).

Arakawa,T.and Timasheff, S.N.1982.Stabilization of protein structure by sugars.”Biochemistry,21:6536-6544.

Crowe,J.H.; Crowe,L.M.;Carpenter,J.F.;Rudolph,A.S.;Wistrom.C.A;Spargo,B.J.andAcnhordoguy.T.J1947.”Interaction of sugars with membrane”. Biochembiophysacta:367-384.

Kossovsky,Gelman.A.and Sponsler, E.E.1994”Crosslinking encapsulated haemoglobin solid phase supports:lipid enveloped haemoglobin adsorbed to surface modified ceramic particles exhibit physiological oxygenlability artif.cells blood sub”biotech,223:479-485.

Jain.N.K.“Advances in controlled drug delivery system”;317-328.

Shahabade Gururaj S, Bhosale Ashok V ,Mutha Swati S, Bhosale Nilesh R, Khade Prashant H.2009. An overview on nanocarrier technology-Aquasomes. Journal of Pharmacy Research, 2(7).

Gholap AD, Borude SS, Mahajan AM, Gholap MAD.2011 Aquasomes:A potential drug delivery carrier.Pharmacol Online.3:230-7.

Mohammad F., Mummidi V. “Aquasome a potential drug carrier for delivering the bioactive molecules” European journal of Pharmaceutical and medical research. 2021 page- 236-243.

Mesariya S,Joshi K, Jain H,Upadhyay U. 2012 Aquasomes—A Self?Assembled Nanotechnology System.ChemInform.;43(30).

Cherian A.K., Rana A.C., Jain S.K.2000. Self-assembled carbohydrate- stabilized ceramic nanoparticles for the parenteral delivery of insulin. Drug Dev IndPharm. 26:459-63.

Oviedo R.I., Lopez S.A.D., Gasga R.J., Barreda C.T.Q. 2007. Elaboration and structural analysis of Aquasomes loaded with indomethecin. Eur J PharmSci. 32:223-230.

Vyas S.P.,Goyal A.K., Rawat A., Mahor S., Gupta P.N., Khatri K.2006. Nano decoysystem: a novel approach to design hepatitis B vaccine for immunopotentiation. Int J Pharm.;309:227-233.

Khopade A.J., Khopade S., Jain N.K. 2002. Development of haemoglobin Aquasomes from spherical hydroxyapatite cores precipitated in the presence of poly(amidoamine) dendrimer.Drug Dev Ind Pharm. 241:145-54

Vyas S.P., Goyal A.K., Khatri K., Mishra N., Mehta A., Vaidya, B., et al. 2008. Aquasomes—a nanoparticulate approach for the delivery of antigen. Drug Dev Ind Pharm. 34:1297-1305.

Kossovsky, N.; Gelman.A. and Sponsler, E.E (1994c) ”Cross linking encapsulated haemoglobin solid phase supports: lipid enveloped haemoglobin adsorbed to surface modified ceramic particles exhibit physiological oxygen lability artif.cells bloodsub”biotech223:479-485.

Kossovsky, N.; Gelman, A; Sponsler, E.; Rajguro, S.; Tones, M; Mena, E.; Ly, K and Festeljian, A (1995a)“Preservation of surface-dependent properties of viral antigens following immobilization on particulate ceramic delivery vehicles.” 1. Biomed.Mater.REs.29, 5:561-573.

Cherian,A.andJainS.K.2000“Selfassembled carbohydrate stabilized ceramic nanoparticles for the parentral drug delivery of insulin”Drug development and industrial pharmacy,26,459-463.

Jadhav P. P., Aloorkr N.H., “A review on aquasomes” International journal of creative research thought. 2021(537-539).

Priya MDK, Kumar V, Damini VK, Eswar K, Reddy KR, Raj BS, Sucharitha P. SOMES: A review on composition, formulation methods and evaluations of different types of “SOMES” drug delivery system. Int J Appl Pharm. 2020;12(6):7-18. Doi:10.22159/ijap.2020v12i6.38996.

Oviedo R.I., Lopez S.A.D., Gasga R.J., Barreda C.T.Q. Elaboration and structural analysis of aquasomes loaded with indomethecin. Eur J Pharm Sci. 2007; 32:223-230.

Jain S. S., JagtapP.S.,Dand N.M., Jadhav K.R., Kadam V.J.,”Aquasomes: A novel drug carrier”, Journal of applied pharmaceutical science(2012) page-184-192.

Published

2024-04-14
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How to Cite

Kumar, G., R. Rani, A. P. Singh, and A. P. Singh. “Aquasomes: An Updated Review”. International Journal of Pharmaceutics and Drug Analysis, vol. 12, no. 1, Apr. 2024, pp. 15-19, doi:10.47957/ijpda.v12i1.571.

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