An updated review on liposomes

Ajay Kumar; Ritu Rani; Rajesh Kumar; Ajeet Pal Singh; Amar Pal Singh

doi:10.47957/ijpda.v12i1.568

Authors

Ajay Kumar Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Ritu Rani Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Rajesh Kumar Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Ajeet Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.
Amar Pal Singh Department of Pharmaceutics, St. Soldier institute of pharmacy, Lidhran Campus, Behind NIT (R.E.C.), Jalandhar –Amritsar by pass, NH-1, Jalandhar -144011, Punjab, India.

DOI:

https://doi.org/10.47957/ijpda.v12i1.568

Keywords:

Liposomes, Vesicles, Drug Delivery, Cholesterol, Phospholipids, dds

Abstract

Liposomes, tiny bubbles made from the same material as a cell membrane, are considered the most successful nanocarriers for drug delivery. They are biocompatible and stable, encapsulating both hydrophilic and lipophilic drugs and protecting them from degradation. Liposomes are the most commonly used drug delivery vehicles due to their high drug trapping capacity and efficiency. These offer controlled release, targeted drug delivery, increased therapeutic efficacy, and reduced dosing frequency. Liposome-based drug formulations have been approved for clinical use and are the subject of extensive research. Recent liposomal formulations aim to reduce toxicity and increase target site accumulation. With numerous advantages, liposomes prove their uniqueness in safe drug delivery in various areas of pharmacy and medicine. We will keep an eye on overall updated review on liposomes classification, their structural components, mechanism of action, stability, method of preparation, their evaluation tests and applications.

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References

Lakpa Sangay Sherpa, Inder Kumar, Amit Chaudhary, Bimit Lepcha, 2020, Liposomal Drug Delivery System: Method of Preparations and Applications, Lakpa Sangay Sherpa et al /J. Pharm. Sci. & Res. Vol.12(9),1192-1197.

Harshita Mishra, Vaishali Chauhan, Kapil Kumar, Deepak Teotia, 25 Nov 2018, A comprehensive review on Liposomes: a novel drug delivery system, Journal of Drug Delivery& Therapeutics.;8(6):400-404.

Hadis Daraee, Ali Etemadi, Mohammad Kouhi, Samira Alimirzalu & Abolfazl Akbarzadeh (2016) Application of liposomes in medicine and drug delivery, Artificial Cells, Nanomedicine, and Biotechnology, 44:1, 381-391, DOI: 10.3109/21691401.2014.953633

Subash Chandran M.P*, Prasobh G.R, Jaghatha T, Aswathy B.S, Remya S.B,An Overview on Liposomal Drug Delivery System, International Journal of Pharmaceutical and Phytopharmacological Research(eIJPPR)|April 2019|Volume9|Issue 2|Page 61-68

Latifa W. Allahou, Seyed Yazdan Madani, and Alexander Seifalian , Investigating the Application of Liposomes as Drug Delivery Systems for the Diagnosis and Treatment of Cancer, International Journal of Biomaterials,Volume 2016,1-16.

Sakib M Moinuddin, Irfan Sajid and Md. Hasanul Arif, Liposomal Drug Delivery System – A Concise Review, Acta Scientific Pharmaceutical Sciences, Volume 6 Issue 1 January 2022,(ISSN:2581-5423)

Sanjida Islam Saiky, Nur E Naznin Chaity1, Sanjida Zaman Mim, Pharmaceutical Liposomes: A Potential Drug Carrier Systems for Novel Drug Delivery,VigyanVarta,Vol-2Issue-1,32-35.

Harshita Mishra,Vaishali Chauhan, Kapil Kumar*,Deepak Teotia, 25 Nov 2018, A comprehensive review on Liposomes: a novel drug delivery system, Journal of Drug Delivery and Therapeutics, 2018;8(6):400-404.

Saha, Puja & Saha, Subhasish. (2023). Liposome. Indian Research Journal of Pharmacy and Science. 10. 2797-2806.

Lombardo, D., & Kiselev, M. A. (2022). Methods of Liposomes Preparation: Formation and Control Factors of Versatile Nanocarriers for Biomedical and Nanomedicine Application. Pharmaceutics, 14(3), 543. https://doi.org/10.3390/pharmaceutics14030543

Alavi, M., Karimi, N., & Safaei, M. (2017). Application of Various Types of Liposomes in Drug Delivery Systems. Advanced pharmaceutical bulletin, 7(1), 3–9. https://doi.org/10.15171/apb.2017.002

Shantanu Pande (2023) Liposomes for drug delivery: review of vesicular composition, factors affecting drug release and drug loading in liposomes, Artificial Cells, Nanomedicine, and Biotechnology, 51:1, 428-440, DOI: 10.1080/21691401.2023.224703

SunithaReddyMandAmulyaEtikala1,9Aug2019,Liposomes-ANovelDrugDeliverySystem:AReview,InternationalJournal of Pharmacy and Biological Sciences,9(4):374-382.

Ammaarah*, KrishnaSailaja A, Liposomes– A Novel Drug Delivery System,South Asian Research Journal of Pharmaceutical Sciences,July-Aug-2020,Volume-2|Issue-4,1-5.

PooriaNakhaei1,RiaMargiana2,3,4DmitryO.Bokov5,Walid Kamal Abdel basset,Liposomes:Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol, Frontiersin Bioengineering and Biotechnology,09 September2021,Volume 9,1-23.

NasimKarami1,Eskandar Moghimipour,Anayatollah Salimi,Liposomes as a Novel Drug Delivery System: Fundamental and Pharmaceutical Application, Asian Journal of Pharmaceutics • Jan-Mar 2018(Suppl)•12(1)| S31-S41.

Mehran Alavi*, Naser Karimi*, Mohsen Safaei, Application of Various Types of Liposomes in Drug Delivery Systems, Advanced Pharmaceutical Bulletin 13 April 2017,7(1),1-9.

Lisa Sercombe, Tejaswi Veerati, Fatemeh Moheimani, SherryY. Wu3, Advances and Challenges of Liposome Assisted Drug Delivery, Frontiersin Pharmacology,01 December 2015,Volume 6,1-13.

Hamdard University, Faculty of Pharmacy Karachi, Pakistan, liposomes: a novel drug deliverysystem,1-14.

Dilip, C. V., & Ravsaheb, M. S. “liposomal drug delivery system: an overview”. International Research Journal of Modernization in Engineering Technology and Science (2023),page-4412-4424.

Durgavati Yadav1, Kumar Sandeep2, Deepak Pandey3 and Ranu Kumari Dutta4*, 2017, Liposomes for Drug Delivery, Journal of Biotechnology &Biomaterials, Volume 7,Issue 4, 1-8.

Ganesh Shankar Sawant1, Kiran Vilas Sutar2, Akhil S. Kanekar3, April 2021, Liposome: A Novel Drug Delivery System, International Journal of Research and Review,Vol.8;Issue:4,252-268.

Arpit Rajaram Suralkar *,Chaitanya Shahaji Khedkar, Nidhi R Zanwar, Chanchal C Chandak and Shital J Gandhi,25 September 2022, Liposomes as a novel drug delivery system,GSC Biological and Pharmaceutical Sciences,20(03),336–343.

SANDEEP KALEPU* SUNILKUMAR K T ,SUDHEER BETHA, MOHANVARMA M, Liposomal drug delivery system – A Comprehensive Review, Int. J. Drug Dev. & Res., October -December 2013, Vol. 5 | Issue 4, 1-14.

Yadav A.V, Murthy M.S, Shete A.S andS furti Sakhare,Stability Aspects of Liposomes,Indian Journal of Pharmaceutical Education and Research,12-4-2011,Vol45/Issue 4,1-12

MustafaGrit*and DaanJ.A.Crommelin,Chemical stability of liposomes”implications for their physical Stability,Elsevier Scientific Publishers Ireland Ltd.,October9th,1992,1-16.

Arpita Singh*, Anchal Srivastava, Amresh Gupta, Liposomal Drug Delivery System– A Review, Journalof Applied Pharmaceutical Sciences and Research, July-September, Journal of Applied Pharmaceutical Sciences and Research,July-September,2020,1-10.

Peng Liu, Guiliang Chen and Jingchen Zhang, AReview of Liposomes as a Drug Delivery System:Current Status of Approved Products, Regulatory Environments, and Future Perspectives, molecules,17February2022,1-23.

Ting Wang,Yingjie Deng,Yehui Geng,Jianping Zou,ZhixuanWang,Preparation of submicronunilamellar liposomes by Freeze-drying double emulsions, Biochimica et Biophysica Acta, 28 February2006,222-231.

Diana Guimaraes a, Artur Cavaco-Paulo a,b,Eug´enia Nogueira a,b,Design of liposomes as drug delivery system for therapeutic applications, International Journal of Pharmaceutics,2April2021,1-15.

Shreya Mahesh Suthar*and Bhargavi Ankit Rathva,March2019,development of liposomal formulation: from formulation to sterilization, World Journal of Pharmaceutical Research, Volume 8,Issue3,1561-1571.

R. R. Thenge, M. P. Chandak*, V. S. Adhao, Liposomes: A Novel Drug Delivery System, International Journal of Pharmacy and Pharmaceutical Research, May 2020 Vol.:18,704-715.

Nakhaei, P., Margiana, R., Bokov, D. O., Abdelbasset, W. K., Jadidi Kouhbanani, M. A., Varma, R. S., Marofi, F., Jarahian, M., & Beheshtkhoo, N. (2021). Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol. Frontiers in bioengineering and biotechnology, 9, 705886. https://doi.org/10.3389/fbioe.2021.705886 (Retraction published Front Bioeng Biotechnol. 2023 Sep 04;11:1285118)

Hadis Daraee, Ali E temadi, Mohammad Kouhi, SamiraAlimirzalu, Applications of liposomes in medicine and drug delivery,Artificial cells,nano medicines and biotechnology2016;44: 381–391

Abdus Samad, Y. Sultana and M. Aqil , Liposomal Drug Delivery Systems: An Update Review, CurrentDrugDelivery,2007,4,297-305.

Temidayo O. B. Olusanya 1 ID , Rita Rushdi Haj Ahmad,Daniel M. Ibegbu, James R. Smith And Amal AliElkordy 1, Liposomal Drug Delivery Systems an Anticancer Drugs,Molecules,14 April2018, 23, 907;doi:10.3390/molecules23040907.

Mohammad Amin Jadidi Kouh banani Rajender S. Varma, Liposomes:Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol, Frontiers in Bioengineering and Biotechnology,09 September 2021,Volume9,1-23.

An updated review on liposomes

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