Design, Development and In-Vitro Characterization of of Cyclobenzaprine Hcl Sustained Release Pellets
DOI:
https://doi.org/10.47957/ijpda.v11i4.563Keywords:
Cyclobenzaprine hydrochloride, extended release pellets, sugar spheres, starch, PVP K-90, ethyl celluloseAbstract
The aim of the present studyisto formulate and evaluate the cyclobenzaprine hydrochloride extended release pellets by Wurster coating method using starch, PVP K-90, ethyl cellulose, isopropyl alcohol, talc and other polymers to release the drug slowly through an extend period of time. The method of preparation of Cyclobenzaprine Hydrochloride SR pellets involves in two steps, namely drug coating and polymer coating. In the drug coating process drug is coated as a suspension form to dummy pellets and dried and sieved. Drug loaded pellets are coated with SR polymer to form SR pellets. These SR pellets are dried, sieved and send to quality control.FTIR studies of the formulation indicating no chemical interaction between cyclobenzaprine HCl and excipients. In order to get the optimized formulation, the various process parameters were adjusted. The various evaluations for formulations were carried out, that to based on the in-vitro drug release studies of F5 formulation shows better drug releaseprofile than other formulations. The results conclude that trial F5 has met the objective of extended release, cost effective as once day of drug.
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