PSYCHOBIOTICS; A NEW FRONTIER IN TREATMENT OF DEPRESSION
DOI:
https://doi.org/10.47957/ijpda.v11i1.534Keywords:
Gut microbiome, Psychobiotics, Depression, Gut Brain axisAbstract
The gut microbiota is a diverse multitude of bacteria, fungi, protozoa and viruses. The gut- brain axis forms a bilateral pathway between the intestinal microbiome and CNS, its collaborative action having both direct and indirect effect in the body. Intestinal dysbiosis is linked to elevated stress, anxiety and depression which alter the normal functioning. The current paradigm focuses on the effect of probiotics on the neurological disorder and how commensal bacteria can reverse action and alleviate depressive symptoms.Various preclinical and clinical studies have shown evidences suggesting the administration of certain probiotic strains have therapeutic effect in cognitive and behavioural disorders. This article reviews on themutualistic association between the gut- brain axis,impact ofgut microbiota in neurologic disorders and the psychotropic effect of probiotics in depressive patients.
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References
Misra S., Mohanty D., Psychobiotics: A new approach for treating mental illness?Critical Reviews in Food Science and Nutrition 2019, 59 (8): 1230-1236
Dinan T.G., Stanton C. Cryan J.F., Psychobiotics: A Novel Class of Psychotropic, Biological Psychiatry, 74(10), 2013,720-726
Sarkar A.,LehtoS.M.,Harty S., Dinan T.J.,Cryan J.F.,5 Burnet P.W.J.,Psychobiotics and the Manipulation of Bacteria–Gut–Brain Signals, Trends in Neurosciences, 39(11), 2016, 763-781
Seki, H., M. Shiohara, T. Matsumura, N. Miyagawa, M. Tanaka, A. Komiyama and S. Kurata, Prevention of antibiotic?associated diarrhea in children by Clostridium butyricum MIYAIRI, Pediatrics International, 45(1), 2003, 86-90
Pennisi E., Meet the “ Psychobiome”: the gut bacteria that may alter how you think, feel, and act, American Association for the Advancement of Science, https://www.sciencemag.org/news/2020/05/meet-psychobiome-gut-bacteria-may-alter-how-you-think-feel-and-act
Carabottia M.,Sciroccoa A. ,Masellib M.A. , SeveriaC.,The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems, Current Opinion in Neurobiology, Vol. 61,2020, 1-9
Kim Y-K., Evrensel A., Ünsalver B.O and Ceylan M.E.,Frontiers in Psychiatry- Psychobiotics
Zhou L., FosterJ.A.,Psychobiotics and the gut–brain axis: in the pursuit of happiness,
Neuropsychiatric Disease and Treatment, Vol.11, 2015, 715-723
T-Barbosa M.D., H-Romero A., G-Amezquita L.E., and G-Cayuela T., Psychobiotics: Mechanisms of Action, Evaluation Methods and Effectiveness in Applications with Food Products, Nutrients, 12(12), 2020, 3896
Smith L.K., Wissel E.F., Microbes and the Mind: How Bacteria Shape Affect, Neurological Processes, Cognition, Social Relationships, Development, and Pathology, Perspectives on Psychological Science: a Journal for the Association for Psychological Science, 14(3), 2019, 397-418
Trzeciak P., Herbet M., Role of the Intestinal Microbiome, Intestinal Barrier and Psychobiotics in Depression, Nutrients, 13(3), 2021,927
Roque S., C-Neves M., Mesquita A,R,, Palha J.A., Sousa N. Interleukin-10: A Key Cytokine in Depression?, Cardiovascular Psychiatry and Neurology, Vol. 2009, Article ID. 187894, 1-5
Smith K.S., Greene M.W., Babu J.R., Frugé A.D., Psychobiotics as treatment for anxiety, depression, and related symptoms: a systematic review, Nutritional Neuroscience, 2019, 1-15
Cheng L-H., Liu Y-W., Wu C-C., Wang S., Tsai Y-C., Psychobiotics in mental health, neurodegenerative and neurodevelopmental disorders, Journal of Food and Drug Analysis, 27 (3), 2019, 632-648
Greener M., Psychobiotics: bacterial hope for depression? Progress in Neurology and Psychiatry, 22(1), 2018, 9-11
Steenbergen L., Sellaro R., Hemert S.V., Bosch J.A., Colzato L.S., A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood, Brain, Behaviour and Immunity, Vol.48, 2015, 258-264
Belgnaoui A.A et al., Bifidobacterium longum and Lactobacillushelveticus synergistically suppress stress-related visceral hypersensitivity through hypothalamic-pituitary-adrenal axis modulation, Journal of Neurogastroenterology and Motility, 24 (1), 2018, 138-146
Jacobs J.P., Mayer E.A., Psychobiotics: Shaping the Mind With Gut Bacteria, The American Journal of Gastroenterology, 114(7), 2019, 1034-1035
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