FORMULATION AND EVALUATION OF ELETRIPTAN HYDRO- BROMIDE MICROSPHERES BY USING NATURAL POLYMERS
Keywords:
Eletriptan, Chitosan, SEM analysis and in-vitro studiesAbstract
Purpose: The aim of present work to develop competent and efficient sustained release microspheres of Eletriptan hydrobromide, prepared by Ionotropic gelation technique in order to reduce the frequency of administration and achieve patient compliance.
Method: Microspheres of Eletriptan hydrobromide were prepared by Ionic gelation method using natural polymers like sodium alginate, chitosan, karaya gum and guar gum. The morphology, particle size distribution and production yield were investigated. Release of Eletriptan hydrobromide was evaluated by In-vitro dissolution method using USP type I apparatus.
Result: Results showed that microspheres were spherical, discrete in shape. The percentage yield of the prepared microspheres was found to be 80.46% to 87.12%. Particle size distribution of the prepared microspheres was in the range of 487.0 – 802.5?m. In-vitro release studies revealed a controlled release of microspheres suitable for preoral administration. Formulation FEC1 showed 90.82% ± 0.26 of drug release for 12 hours in predetermined rate.
Conclusion: Based on the results the formulation FEC1 was found to be best when compared to other formulations.
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