A Review on Herbal Drugs used for the Treatment of Diabetes Mellitus

Authors

  • Priyanka Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Surya Prakash Gautam Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Kapil Kanwar Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Daisy Sharma Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Narinder Singh Department of Pharmaceutics, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.
  • Rajinderpal Kaur Department of Pharmacology, CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar.

Keywords:

Antidiabetic, Medicinal plant, India, Herbal drugs

Abstract

Traditional Medicines derived from therapeutic plants are utilized by around 60% of the total populace. This review focuses on Herbal medications and plants utilized as a part of the treatment of diabetes, particularly in India. Plants have dependably been a wellspring of medications for people since time immemorial. The Indian customary arrangement of pharmaceutical is packed with the utilization of plants for the administration of diabetic conditions. The World Health Organization (WHO) has recorded 21,000 plants, which are utilized for therapeutic purposes far and wide. Natural meds have been exceedingly regarded source of prescription all through the mankind's history. Various studies have affirmed the advantages of therapeutic plants with hostile to hyperglycemic impacts in the administration of diabetes mellitus. History demonstrated that therapeutic plants have been utilized as a part of customary recuperating far and wide for quite a while to treat diabetes; this is on account of such natural plants have hypoglycemic properties and other gainful properties.

Downloads

Download data is not yet available.

References

Keter LK, MutisoPC.Ethnobotanical studies of medicinal plants used by Traditional Health practitioners in the management of diabetes in Lower Eastern Province, Kenya. J of Ethno-pharmacol.2012;139(1):74–80.

Dong H, Wang N, Zhao . Lu F.Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine.2012;12:1-12.

Waxler-Morrison NE. Plural medicine in Sri Lanka: Do Ayurvedic and Western medical practice differ, SocSci Med 1988; 27: 531-44.

Dahanukar SA, Kulkarni RA, Rege NN. Pharmacology of Medicinal Plants and Natural Products.Indian J Pharmacol. 2000; 32:S81–S118.

Pulok KM, Kuntal M, Kakali M, Peter JH. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol.2006; 106:1–28.

Mohamed B, Abderrahim Z, Hassane M, Abdelhafid T, Abdelkhaleq L. Medicinal plants with potential antidiabetic activity-A review of ten years of herbal medicine research.Int J Diabetes Metabol.2006;14:1-25.

Sarkodie J.A., Fleischer T.C., Edoh D.A., Dickson R.A., Mensah M.L.K., Annan K., Woode E. Koffour G.A,. Appiah A.A, and Brew-Daniels H.Antihyperglycaemic activity of ethanolic extract of the stem of Adenialobata (passifloraceae) IJPSR, 2013; 4(4): 1370-1377.

Cetto A.A, H. Wiedenfeld. Hypoglycemic effect of Acosmiumpanamensebark on streptozotocin diabetic rats.J. Ethnopharmacology,2004; 90: 217-220.

Aguilar F.J.A., Ramos R.R., Estrada M.J., Chilpa R.R., Peredes B.G. and Flores S.J.L. Effects of three Mexi-can medicinal plants (Asteraceae) on blood glucose levels on healthy mice and rabbits, J. Ethnopharmacology,1997; 55: 171-177.

Xie JT, Wang CZ, Li XL, Ni M, Fishbein A, Yuan CS.Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: comparison between American ginseng and Scutellariabaicalensis using an ob/ob mice model. Fitoterapia. 2009 ;80(5):306-11

Sokeng S.D., Lontsi D., Moundipa P.F., Jatsa H.B., Watcho P. and Kamtchouing P. Hypoglycemic Effect of AnacardiumoccidentaleL. Methanol Extract and Fractions on Streptozotocin-induced Diabetic Rats, Global Journal of Pharmacology 2007; 1 (1): 01-05

Subramonian A., Pushpangadan P., Rajasekharan S., Evan D.A., Latha P.G. and Valsaraj R.: Effects of Artemisia pallensWall. on blood glucose levels in normal and alloxan induced diabetic rats, J. Ethnopharmacology,1996; 50 (1): 13-17

Nofal S.M., Mahmoud SS, Ramadan A, Soliman GA and Fawzy R.: Antidiabetic effect of Artemisia judai-caExtracts, Research Journal of Medicine and Medical Sciences, 2009;4(1): 42-48.

Sunmonu T. O and Afolayan A. J. Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afraAqueous Extract in Wistar Rats. Evidence-Based Complementary and Alternative Medicine.2013:1-8

Sener G, Özsoy-Sacan Ö, Yanardag R, Ayanoglu-Dulger G. Effects of chard (Beta vulgaris L. var. cicla) extract on oxidative injury in the aorta and heart of streptozotocin-diabetic rats, J Med Food. 2002 ;5(1):37-42.

AnandaPrabu K, Kumarappan CT, Christudas S, Kalaichelvan VK. Effect of Biophytumsensitivumon streptozotocin and nicotinamide induced diabetic rats. Asian Pac J Trop Biomed.2012; 2(1): 31-35.

Suba V., Murugesan T., Rao R.B., Ghosh L., Pal M., Mandal S.C. and Saha B.P. Antidiabetic potential of Barlerialupulinaextract in rats. Fitoterapia,2004;75: 1-4

Fuenter O., Avila P.A. and Alarcon J. Hypoglycemic activity of Bauhinia candicansin diabetic induced rabbits, Fitoterapia, 2004; 75: 527-532.

Singh J, Kakkar P. Antihyperglycemic and antioxidant effect of Berberisaristataroot extract and its role in regulating carbohydrate metabolism in diabetic rats. J Ethnopharmacol. 2009; 123:22-6.

Pandikumar P., Babu N.P., Ignacimuthu S., Hypoglycemic and antihyperglycemic effect of Begonia malabarica Lam. in normal and streptozotocin induced diabetic rats. J Ethnopharmacol,2009;124:111-5

Patil R.N., Patil R.Y., Ahirwar D. Study of some medicinal plants for antidiabetic activity in alloxan induced diabetes rats. Pharmacologyonline, 2010; 1: 53-60.

Purohit A. and Sharma A., Antidiabetic efficacy of Bougainvillea spectabilisbark extract in streptozotocin induced diabetic rats, J. Cell and Tissue Research,2006; 6 (1): 537-540

T hirumalai T, ViviyanTherasa S, Elumalai EK, David E. Hypoglycemic effect of Brassica juncea(seeds) on streptozotocin induced diabetic male albino rat. Asian Pac J Trop Biomed 2011;1(4): 323-325

Koti B.C., Maddi V.S., Jamakandi V.G. and Patil P.A., Effect of crude petroleum ether extract of Brassica oleraceaon euglycemic and alloxan induced hyperglycemic albino rats, Indian Drugs.2004;41 (1): 54-55

Sharma N., Garg V. Antidiabetic and antioxidant potential of ethanolic extract of Butea-monospermaleaves in alloxan-induced diabetic mice, Indian J BiochemBiophys, 2009;46(1):99-105.

Jana K., Chatterjee K., Ali K.M., De D., Bera T.K., Ghosh D. Antihyperglycemic and antioxidative effects of the hydro-methanolic extract of the seeds of Caesalpiniabonducellaon streptozotocin-induced diabetes in male albino rats, Pharmacognosy Res., 2012; 4(1):57-62

Lemhadri A., Zeggwagh N.A., Maghrani M., Jouad H., Michal J.B. and Eddouks M. Hypoglycemic effect of CalaminthaofficinalisMoench. in normal and streptozotocin induced diabetic rats, J. Pharm. Pharmacology,2004; 56: 795-799

Islam M.S., Effects of the aqueous extract of white tea (Camellia sinensis) in a streptozotocin-induced diabetes model of rats, Phytomedicine., 2011;19(1):25-31

6Juarez-Rojop IE, Díaz-Zagoya JC, Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats, BMC Complement Altern Med. 2012; 12:236

Rasineni K, Bellamkonda R, Singareddy SR, Desireddy S., Antihyperglycemic activity of Catharanthus-roseusleaf powder in streptozotocin-induced diabetic rats, Pharmacognosy Res.,2010; 2(3): 195–201

Suresh B., Rajkapoor B. and Jayakar B. Effect of Carallumaattenuatain normal and alloxan induced diabetic rats, J. Herbal Pharmacotherapy,2004; 4 (1): 35-40

Salahuddin M., Jalalpure S.S., Antidiabetic activity of aqueous fruit extracts of CucumistrigonusRoxb. instreptozotocin-induced-diabetic rats, J Ethnopharmacol. 2010; 127(2):565-7.

Kuroda M., Mimaki Y., Nishiyama T., Mae T., Kishida H., Tsukagawa M., Takahashi K., Kawada T., Nakagawa K. and Kitahara M Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice, Biol Pharm Bull; 2005; 28(5):937-9.

Díaz-Flores M., Angeles-Mejia S., Baiza-Gutman LA., Medina-Navarro R., Hernández-Saavedra D., Or-tega-Camarillo C., Roman-Ramos R., Cruz M. and AlarcAguilar FJEffect of an aqueous extract of Cucurbitaficifolia Bouche on the glutathione redox cycle in mice with STZ-induced diabetes, J Ethnopharmacol.2012; 144(1):101-8.

Mukhtar H.M., Ansari S.H., Ali M., Bhat Z.A. and Naved T. Effect of aqueous extract of Cyamopsistetra-gonolobaLinn. beans on blood glucose level in normal and alloxan-induced diabetic rats, Ind. J. Exp. Biology ,2004;42 (12):1212-1215

Annapurna A., Koteswara N.R., Krishna R.R.V., Kota M.K., Nammi S. and Murthy B.K., Evaluation of hypoglycemic and antihyperglycemic effects of Daturametel(Linn) seeds in normal and alloxan-induced diabetic rats, J. Ethnopharmacology,2004;91: 95-98

Kumar S., Kumar V., Prakash O., Antidiabetic, hypolipidemic and histopathological analysis of Dilleniaindica (L.) leaves extract on alloxan induced diabetic rats. Asian Pac J Trop Med, 2011; 4(5):347-352.

Kiran V. Pund, Neeraj S. Vyawahare, Rajendra T. Gadakh, Vilas K. Murkute.. Antidiabetic Evaluation of DalbergiaSissooagainst alloxan induced diabetes mellitus in wistar albino rats, J. Nat. Prod. Plant Resour., 2012; 2 (1): 81-88

Nain P., Saini V., Sharma S., Nain J., Antidiabetic and antioxidant potential of Emblicaoffici-nalisGaertnleaves extract in streptozotocin-induced type-2 diabetes mellitus (T2DM) rats. J Ethnopharmacol. 2012; 142(1):65-71

Matsumura T., Kasai M., Hayashi T., Arisawa M.Y., Arai I., Amagaya S. and Komatsu Y. A glucosidase inhibitors from Paraguanyan natural medicine, Nangapiry, the leaves of Eugenia uniflora,Pharmaceutical Biology,2000; 38 (4): 302-307

Ahlema S., Khaleda H., Wafaa M., Sofianeb B., Mohameda D., Claude M.J., Oral administration of Eucalyptus globulusextract reduces the alloxan-induced oxidative stress in rat. ChemBiol Interact 2009; 181: 71-76

Bhaskara R.R., Murugesn T., Sinha S., Saha B.P., Pal M. and Mandal S.S., Glucose lowering efficacy of Ficusracemosabark extract in normal and alloxan diabetic rats, Phytother. Research,2002; 16 (6): 590-592

Ghosh, R., K.H. Sharatchandra, S. Rita and I.S. Thokchom. 2004. Hypoglycemic activity of Ficushis-pida(bark) in normal and diabetic albino rats, Ind. J. Pharmacology 36 (4): 222-225

Shirwaikar A., Rajendran K., Barik R., Effect of aqueous bark extract of GarugapinnataRoxb. instreptozotocin-nicotinamide induced type-II diabetes mellitus, J Ethnopharmacol. 2006; 107(2):285-90.

Mall G K, Mishra P K , Prakash V. Antidiabetic and Hypolipidemic Activity of Gymne-masylvestreinAlloxan Induced Diabetic Rats, Global J. Biotech. & Biochem.,2009; 4 (1): 37-42,

Malalavidhane T.S., Wickramasinghe S.M.D.N., Perera M.S.A. and Jansz E.R. Oral hypoglycemic activity of Ipomoea aquaticain streptozotocin induced diabetic wistar rats and type-II diabetes, Phytother. Research,2003;17 (9): 1098-1100

Ajani H. B., Patel H. P., Shah G. B., Acharya S. R. and Shah S. K.. Evaluation of antidiabetic effect of methanolic extract of Inularacemosaroot in rats, Pharmacologyonline,2009; 3: 118-129

Izharul H. and Khatoon S., Effect of momordicacharantia (bitter gourd) tablets indiabetes mellitus: Type 1 and Type 2 , Prime Research on Medicine 2012; 2(2): 72-74

Gandhi G.R., Sasikumar P., Antidiabetic effect of MerremiaemarginataBurm. F. in streptozotocin induced diabetic rats, Asian Pac J Trop Biomed. 2012; 2(4):281-6

Nerurkar P.V., Nishioka A., Eck P.O., Johns L.M., Volper E., Nerurkar V.R., Regulation of glucose metabolism via hepatic forkhead transcription factor 1 (FoxO1) by Morindacitrifolia (noni) in high-fat diet-induced obese mice, Br J Nutr., 2012;108(2):218-28.

Vinuthan M.K., Kumar G.K., Ravindra J.P., Prakash J. and Narayana K., Effect of extracts of Murrayakoengiileaves on the levels of blood glucose & plasma insulin in alloxan induced diabetic rats, Ind. J. Physiol. Pharmacology,2004; 48 (3): 348-352

Bhaskar A., Vidhya V.G. and Ramya M., Hypoglycemic effect of Mucunapruriens seed extract on normal and streptozotocindiabetic rats. Fitoterapia, 2008; 79: 539-543.

Ebrahimpur M.R., Khaksar Z., Noorafsan A., Antidiabetic Effect of Otostegiapersica Oral Extract on Streptozotocin-Diabetic Rats, Research Journal of Biological Sciences ,2009;4(12) :1227-1229.

Jain S., Bhatia G., Barik R., Kumar P., Jain A., Dixit V.K., Antidiabetic activity of Paspalum-scrobiculatumLinn. In alloxan induced diabetic rats, J Ethnopharmacol. 2010; 127(2):325-8.

Mard S.A., Jalalvand K., Jafarinejad M., Balochi H., NaseriM.K.,Evaluation of the antidiabetic and antili-paemic activities of the hydroalcoholic extract of phoenix dactyliferapalm leaves and its fractions in alloxan-induced diabetic rats, Malays J Med Sci., 2010; 17(4):4-13.

Viswanathaswamy A.H., Koti B.C., Gore A., Thippeswamy A.H., Kulkarni R.V., Antihyperglycemic and antihyperlipidemic activity of plectranthusamboinicus on normal and alloxan-induced diabetic rats, Indian J Pharm Sci., 2011;73(2):139-45.

Kondeti V.K., Badri K.R., Maddirala D.R., Thur S.K., Fatima S.S., Kasetti R.B., RaoC.A., Effect of Pterocar-pussantalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats, Food ChemToxicol., 2010; 48(5):1281-7.

Kulkarni C.R., Joglekar M.M., Patil S.B., Arvindekar A.U., Antihyperglycemic and antihyperlipidemic effect of Santalum album in streptozotocin induced diabetic rats, Pharm Biol. 2012; 50(3):360-5.

Datusalia A.K., Dora C.P., Sharma S., Acute and chronic hypoglycemic activity of Sidatiagii fruits in N5-streptozotocin diabetic rats, Acta Pol Pharm., 2012; 69(4):699-706.

Musabayane C.T., Mahlalela N., Shode F.O. and Ojewole J.A.O.,. Effects of Syzygiumcordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocin-induced diabetic rats, J. Ethnopharmacology 2005; 97: 485–490.

Mohammed F., Mohammed A., Ghori S., Ali S., Antidiabetic Activity of VincaroseaExtracts in Alloxan-Induced Diabetic Rats, 2010. International Journal of Endocrinology Volume 2010 ;Article ID 841090

Adaramoye O., Amanlou M., Habibi-Rezaei M., Pasalar P., Ali M.M., Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats, Asian Pac J Trop Med. 2012;5(6):427-33.

Udayakumar R, Kasthurirengan S, Mariashibu TS, et al. Hypoglycaemic and hypolipidaemic effects of Withaniasomniferaroot and leaf extracts on alloxan-induced diabetic rats, Int J Mol Sci. 2009; 10(5):2367-82.

Bhatia A. and Khera N. Hypoglycaemic activity of orally administered Woodfordiafruticosaflower extract in Alloxan-induced diabetic mice, Int. J. LifeSc. Bt& Pharm. Res. 2013; 2(2): 72

Iranloye B.O., Arikawe A.P., Rotimi G., SogbadeA.O.,Anti-diabetic and anti-oxidant effects of Zingiberofficinaleon alloxan-induced and insulin-resistant diabetic male rats, Niger J Physiol Sci.2011; 26(1):89-96.

Abdel-Zaher A.O., Safa Y.S., Mahmoud H.A. and Abdel-Hady R.H., Antidiabetic activity and toxicity of Zizyphusspina-christileaves. J. Ethnopharmacology,2005;101: 129–13.

Published

2017-03-21
Statistics
94 Views | 47 Downloads
Citatons

How to Cite

Priyanka, Surya Prakash Gautam, Kapil Kanwar, Daisy Sharma, Narinder Singh, and Rajinderpal Kaur. “A Review on Herbal Drugs Used for the Treatment of Diabetes Mellitus”. International Journal of Pharmaceutics and Drug Analysis, vol. 5, no. 3, Mar. 2017, pp. 67-76, https://ijpda.org/index.php/journal/article/view/270.

Issue

Section

Review Articles
Share |