Thermal And X Ray Crystallographic Study in Formulations
Keywords:
Incompatibility, Excipient, Thermal analysis, X ray DiffractionAbstract
Thermal techniques and X ray crystallography are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others and used to determine the arrangement of atoms of a crystalline solid in three dimensional spaces respectively. In pharmaceutical industries drug excipient physicochemical characterization is a systematic approach towards design of therapeutically active and stable dosage forms. For high resolution were used to get an insight on solid state properties of the drug and evaluate drug-excipient compatibility this analytical techniques are mainly used. This article contains considerations and interpretation of the graphical data obtained from these techniques.
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SkoogDouglous A, F James Holler and Timothy, Niemen. Principles of Instrumental Analsis Fifth edition New York, 905-908.)
Willard, Merritt, Dean, Settle Instrumental methods of Analysis seventh edition 372-380,761-777.
Frank settle Handbook of Instrumental Techniques For Analytical Chemistrey 339-357,991-930.
James Swarbrik encyclopedia of Pharmaceutical Technology second edition vol-1 and 3 289-301, 2766-2793, 3005-3019.
MichioSorai, Comprehensive Handbook of Calorimetry and Thermal Analysis Edn 1st, 445-472, 3- 54.
James W. Dodd, KennethH.Tonge Edn 1st Wiley India,1-30,110-123,144-164.
Clive Whiston X Ray Methods, Wiley India, 45-66, 66-132.
Campbell and White,Alexander X-Ray diffraction Methods in Polymer Science 80
V.A. Drebuschchak.Thermoanalytical Investigation of drug- exipient interaction Journal of Thermoanalysis and Calorimetry vol90, 2005,210-213
H.K.Stulzer, P.O Rodrigues. Compatibility Studies between Captopril and Pharmaceutical Exipients Used in Tablet formulation,Journal of Thermoanalysis and Calorimetry vol91 2007,323-328.
C.P Rosel ,J.Sepulveda Carreno. Inclusion Complex of the Antiviral.Quimica Nova Dec2000 vol-23 n6 SciELO Brasil.
MakotaOtsuka, Fumie Kato and Yoshida Matsuda.Comparative Evaluation of Degree of Indomethacin crystallinity by Conventional Powder X-ray Diffractometry.AAPS PharmaSci Tech 2002 2(1) Article 9.
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