Hypothyroidism: Management Based On Ayurvedic and Modern Therapeutic Perspective
Keywords:
Hypothyroidism, Herbal plants, Tridosha, Levothyroxine, AyurvedaAbstract
Hypothyroidism is the pathological condition in which the level of thyroid hormones declines to the deficiency state. This communication address the therapies employed for the management of hypothyroidism as per the Ayurvedic and modern therapeutic perspectives on the basis scientific papers collected from accepted scientific basis like Google, Google Scholar, PubMed, Science Direct, using various keywords. The Ayurveda describe hypothyroidism as the state of imbalance of Tridoshas and suggest the treatment via use of herbal plant extracts, life style modifications like practicing yoga and various dietary supplements. The modern medicine practice define hypothyroidism as the disease state originated due to formation of antibodies against thyroid gland and hormonal imbalance and incorporate the use of hormone replacement i.e. Levothyroxine, antioxidants. Various plants like Crataeva nurvula and dietary supplements like Capsaicin, Forskolin, Echinacea, Ginseng and Bladderwrack can serve as a potential area of research as thyrotropic agents.
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Unnikrishnan A, Bantwal G, John M, et. al. Prevalence of hypothyroidism in adults: an epidemiological study in eight cities of India. Indian J. Endocrinol. Metab. 2013; 17: 647-652.
Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002; 87:489-499.
Radetti G, Clinical aspects of Hashimoto’s thyroiditis. Endocrine Development, 2014; 26: 158–170.
Kadlaskar BB, Lakshmi R, Hypothyroidism in Ayurveda - A conceptual study. Ayushdhara, An International Journal of Research in AYUSH and Allied systems, 2015; 2(4): 246-250.
Hubale KS, Patil VS, Location and applied physiology of the thyroid Gland- An Ayurvedic Perspective. International Ayurvedic Medical Journal, 2015; 3(12): 2368-2374.
MaharshiSushruta. SushrutaSamhita, Sutrasthana, Edited by Anantram Sharma, Edition 2010, Vol 15/47, Chaukhamba Surbharati Prakashan, Varanasi:130, 2010.
Roberts CGP, Ladenson Paul W. Hypothyroidism. The Lancet. 2004; 363: 793-803.
BasVN, Cangul H, Agladioglu SY, et al. Mild and severe congenital primary hypothyroidism in two patients by thyrotropin receptor (TSHR) gene mutation. J Pediatr Endocrinol Metab. 2012; 25: 1153-1156.
Carvalho A, Hermanns P, Rodrigues AL, et al. A new PAX8 mutation causing congenital hy-pothyroidism in three generations of family is associated with abnormalities in the urogenital tract. Thyroid, 2013; 23: 1074-1078.
Nakamura K, Sekijima Y, Nagamatsu K, et al. A novel non-sense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea. J Neurol Sci. 2012; 313: 189-192.
Persani L. Central hypothyroidism: pathogenic, diagnostic and therapeutic challenges. J Clin Endocrinol Metab 2012; 97(9):3068–78.
Joustra SD, van Trotsenburg AS, Sun Y, et al. The IGSF1 deficiency syndrome: a newly uncovered endocrinopathy. Orphanet Journal of Rare Diseases, 2013; 1: e24883.
Charaka Samhita of Agnivesha elaborated by Charaka and Drudhabala with the Ayurveda Dipika commentary by Chakrapani dutta, Sutrasthana, Edited by: Vaidya Jadavji Trikamji Chapter- 28, Verse No-9-22:179.
Vagbhata,Ashtanghrudayam,Sutrasthana,Doshabhediya Adhyaya, Edited by Kaviraj Atridev Gupta, Vaidya Yadunandan Upadhyaya, Chaukhamba Prakashan, 12/5, Edition 2011: 120.
Almandoz JP, Gharib H, Hypothyroidism: Etiology, diagnosis, and management. Med Clin N Am, 2012; 96: 203-221.
Sharma RK, Dash B. Charaka Samhita. Chaukhambha Sanskrit Series, Varanasi, India, Vimansthana, verses: 8-9.
Devdhar M, Ousman Y, Burman K. Hypothyroidism. Endocrinol Metab Clin North Am 2007;36:595–615.
Dubbs SB, Spangler R. Hypothyroidism: Causes, killers, and life-saving treatment. Emerg Med Clin N Am. 2014; 32; 303–317.
Garber JR, Cobin RH, Gharib H, et al. Clinical Practice guidelinesfor hypothyroidism in adults: cospon-sered by the American Association of Clinical Endocrinologists and The American Thyroid Association. Endocrine Practice, 2012; 18 (6): 988-1028.
Ianiro G, Mangiola F, Di Rienzo TA, Bibbo S, et al. Levothyroxine absorption in health and disease, and new therapeutic prospective. European review for Medical and Pharmacological Sciences, 2014;18:451-456.
Celi FS, Zemskova M, Linderman JD, et al. The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. Clinical Endocrinology, 2010; 72: 709-715.
Klein I, Ojamaa K, Danzi S. Methods for treating hypothyroidism. US 20050176829 A1: 2005.
Panthi S, Gao T. Diagnosis and management of primary hypothyroidism in Traditional Chinese medicine (TCM) and Traditional Indian Medicine (Ayurveda). International Journal of Clinical Endocrinology and Metabolism, 2015; 1(1):009-012.
Kunte AM, Shastri KR. Vaghbhata Ashtanga Hridayam with Sarvanga sundara and Ayurvada Rasayana Commentary. Chaukhambha Orientalia, Varanasi, India, 2005;956:10.
Mishra LC. Scientific Basis for Ayurvedic Therapies (Ed). CRC Press, New York, USA, 2004:34.
Swami R. Yoga, Its Philosophy and Practice. Divya Prakashan Hardwar India, 2007.
World Health Organization, Geneva. WHO monographs on selected medicinal plants. 1999;1:7. Retrieved from website http://apps.who.int/medicinedocs/en/d/Js2200e/2.html
Sharma T, Gupta M, Nathani S . Review of Ayurvedic drugs acting on hypothyroidism. International Ayurvedic Medical journal, 2015; 3 (8): 2572-2579.
Verma P, Jameel K. Studies on traditional treatment of thyroid by the tribals of chitrakoot district, Uttar Pradesh. International Journal of Science and Research, 2014; 3 (10): 1370-1373.
Sinha MP, Tabassum W, Kullu AR. Effect of leaf extract of Moringa Oleifera on regulation of hypothyroidism and lipid profile. The Bioscan, An International Quarterly Journal of Lifesciences. 2013; 8(2): 665-669.
Parmar HS, Kar A. Protective role of Mangifera indica, Cucumis melo, Citrullus vulgaris peel extracts in chemically induced hypothyroidism. Chemico-Biological Interactions, 2009; 177: 254-258.
Khattar V, Wal A. Utilities of Crataeva nurvala. International Journal of Pharmacy and Pharmaceutical Sciences, 2012; 4 (4): 21-26.
Udaysing HP, Gaikwad DK. Medicinal profile of a scared Drug in Ayurveda : Crataeva religiosa A re-view. Journal of Pharmaceutical Sciences and Research,2011; 3 (1): 923-929.
Sikarwar MS, Patil MB. Antihyperlipidemic activity of Crataeva nurvala Stem bark Extracts, Indian Journal of Pharmaceutical Education and Research, 2012; 46(4): 378-382.
Coleus forskohlii monograph, Alternative medicine review, 2006; 11(1): 47-51.
Bove M, et al. Thyroid disorder: Hypothyroidism & Hyperthyroidism. Endocrine Disorders and Adrenal support 2010; 186-197.
Heisler S, Reisine T. Forskolin stimulates adenylate cyclase activity, cyclic AMP accumula-tion,adrenocorticotropin secreation from mouse anterior pituitary tumor cells. Journal of Neurochemistry, 1984; 42 (6): 1659-1666.
Vyacheslav NT, Yulia AE, Konstantin GE, Natalia VK. Biologically active food additive for normalizing the function of the thyroid gland , US patent vide US20140220071 A1, asigned to JSC Patent Attorney, 2011.
Nelson EK, Dawson LE. The constitution of capsaicin, the
pungent principle of capsicum. J Am Chem Soc , 1923; 45: 2179–2181.
Masuda Y, Haramizu S, Oki K, et al. Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol. 2003;95:2408-2415.
Bianco AC, Sheng X,Silva JE, Triiodo thyronine Amplifies Norepinephrine Stimulation of Uncoupling Protein Gene Transcription by a Mechanism Not Requiring Protein Synthesis. The Journal of Biological Chemistry, 1988; 263 (34): 18168-18175.
Khare CP. Indian Medicinal Plants. Springer - Verlag Berlin/Heidelberg, 2007;177.
Xiaohua D, Yixuan Z, Xingqun YU, Mingxiang H. Effect og ginseng injection on Congestive heart failure and thyroid hormones. CJIM, 2000; 6(1): 29-31.
Skibola CF. The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report. BMC Complement Altern Med. 2004;4:10.
Poon WT, Ng SW, Lai CK, Chan YW, Mak WL. Factitious thyrotoxicosis and herbal dietary supplement for weight reduction. Clin Toxicol. 2008; 46(4):290–292.
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