FORMULATION AND EVALUATION OF PIROXICAM DELAYED RELEASE TABLETS

Abstract

The present investigation of Piroxicam delayed release tablets, many research studies have completed the solution of above mentioned Non steroidal anti inflammatory drug one technology among of all to provide drug with enteric coated polymers so delay release and make release of drug in proximal small intestine. The sugar spheres will be taken into a FBP and drug will be coated onto the spheres and then they will be sub coated and enteric coated. The enteric coated pellets will be compressed into tablets by direct compression. The tablets will be prepared by using sugar spheres HPMC3cps, HPMC5cps, EL30D5, GMS, TEC etc. The prepared tablet will be coated by using pink and various parameters evaluated as per standard procedure.  The FTIR studies will be conducted for optimized formula to prove that the formulas will no incompatibility between the drug and excipients. The drug release profile will be compared with the innovator, formulation has shown similar results, and it was said to be optimized of all formulations. Piroxicam is mainly used to reduce pain, swelling, and joint stiffness from arthritis. Reducing these symptoms helps you do more of your normal daily activities. They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. Piroxicam blocks the enzyme that makes prostaglandins, resulting in lower concentrations of prostaglandins in body.