Speciation Studies of Phenylalanine complexes of Ca(II), Mg(II) and Zn(II) in acetonitrile-water mixtures
Keywords:
Complex equilibria, Chemical speciation, Phenylalanine, Acetonitrile, MetalsAbstract
Equilibrium study on complex formation of Phenylalanine with Ca(II), Mg(II) and Zn(II) has been investigated pH metrically in acetonitrile-water mixtures 0.0-60.0% v/v at 303.0 K and 0.16 M ionic strength. The predominant species detected for Ca(II), Mg(II) and Zn(II) are ML, ML2 and ML2H2.. Models containing different numbers of species were refined by using the computer program MINIQUAD75. The best-fit chemical models were arrived at based on statistical parameters. The trend in variation of complex stability constants with change in the dielectric constant of the medium is explained on the basis of electrostatic and non-electrostatic forces.
Downloads
References
W. M. Haynes, ed., CRC Handbook of Chemistry and Physics, CRC Press/Taylor and Francis, Boca Raton, FL, 95th Edition, Internet Version 2015, accessed December 2014.
Tables of Physical & Chemical Constants, Kaye & Laby Online, 16th edition, 1995. Version 1.0 (2005), accessed December 2014.
J. S. Coursey, D. J. Schwab, J.J. Tsai, and R. A. Dragoset, Atomic Weights and Isotopic Compositions(version 3.0), 2010, National Institute of Standards and Technology, Gaithersburg, MD, accessed December 2014.
T. L. Cottrell, The Strengths of Chemical Bonds, Butterworth, London, 1954.
John Emsley, Nature’s Building Blocks: An A-Z Guide to the Elements, Oxford University Press, New York, 2nd Edition, 2011.
Thomas Jefferson National Accelerator Facility - Office of Science Education, It’s Elemental - The Periodic Table of Elements, accessed December 2014.
Brown E. M. and Hebert S. C. Bone, 20, 303 (1977).
Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National Academy Press, Washington DC (1997).
Weaver C. M. and Heaney R. P. Calcium. In: Shils M. E., Shike M., Ross A. C., Caballero B. and Cousins R. J. Modern Nutrition in Health and Disease. 10th ed. Lippincott Williams and Wilkins, Baltimore (2006).
Heaney R. P., Recker R. R., Stegman M. R. and Moy A. J. J. Bone Miner. Res., 4, 469 (1989).
Shils M. E., Olson J. A. and Shike M. (Eds) Modern nutrition in health and disease, 8th ed, Lea & Febiger, Philadelphia, 164 (1994).
Quamme G. A. Kidney Int., 52, 1180 (1997).
Grubbs R. D. and Maguire M. E. Magnesium as a regulatory cation Criteria and evaluation, Review, PubMed, 6, 113 (1987).
Williams R. J. P. Q. Rev. Chem. Soc., 24, 331 (1970).
Flatman P. W. Annu. Rev. Physiol., 53, 259 (1991).
Weaver C. M. and Heaney R. P. Calcif. Tissue Int., 49, 244 (1991).
Cowan J. A. Introduction to the biological chemistry of magnesium, VCH, New York (1995).
Black C. B. and Cowan J. A. Magnesium-dependent enzymes in nucleic acid biochemistry. VCH, New York (1995).
Cowan J. A. BioMetals, 15, 225 (2002).
Lin, Y. L. and Lim, C. J., J. Am. Chem. Soc. 126 (2004) 2602.
Cox, E. H. and McLendon, G. L., Curr. Opin. Chem. Boil. 4 (2000) 162.
Laity, J. H., Lee, B. M. J. and Wright, P. E., Curr. Opin. Struct. Boil. 11 (2001) 39.
Dudev, T. and Lim, C. J., J. Chin. Chem. Soc. 50 (2003) 1093.
Whitney, E. and Rolfer, S. R., Understanding Nutrition, 10th Ed. Thomson learning (2005) 447.
Stipnuk, M. H. and Martha, H., Biochemical, Physiological and Molecular Aspects of Human Nutrition. W.B. Saunders Company, NY (2006) 1043.
Penland, J. G., FASEB J. 5 (1991) 938.
Milne, D. B., Johnson, P. E. and Gallagher, S. K., Am. J. Clin. Nutr. 53 (1991) 25.
Klevay, L. M., Wilson, G. and Medeiror, D. M., Nutr. Res. 14 (1994) 1227.
Nelson, D. L., Cox, M. M. "Lehninger, Principles of Biochemistry" 3rd Ed. Worth Publishing: New York, 2000.
Loudon, Mark G (2002) Organic Chemistry, 4th ed., Oxford University Press, New York. p 317
Laubengayer AW and Sears DS (1945) Donor-acceptor bonding, III. Methyl cyanide addition compounds of boron trichloride and boron trifluoride. J. Am. Chem. Soc., 67:164-167
Fritz JS and Yamamura SS (1955) Rapid microtitration of sulfate. Anal. Chem., 27:1461-1464
Aktas AH, Sanli N and Pekcan G (2006) Spectrometric determination of pKa values for some phenolic compounds in acetonitrile-water mixture. Acta Chim. Slov., 53:214-218
Sreevaram T, Vijaya Kumar N and Sailaja BBV* “Influence of dielectric constant on protonation equilibria of Phenylalanine and Maleic acid in Ethylene glycol water mixtures”, Chemical Speciation and Bio Availability (communicated) 2015.
Sreevaram T, Vijaya Kumar N and Sailaja BBV* “Effect of Organic Solvent Dielectric Constant on Protonation Equilibria of Phenylalanine and Maleic acid”, Actachem Slovanica (communicated) 2015.)
Gran G (1952) Determination of the equivalence points in potentiometric titrations-Part-II. Analyst 77:661-671
Gran G (1988) Equivalence volumes in potentiometric titrations. Anal. Chim. Acta 206:111-123
Sailaja BBV, Kebede T, Rao GN and Rao MSP (2004) Effect of micells on speciation of ternary complexes of uranyl(VI) with oxalic and melonic acids. Proc. Nat. Acad. Sci. India 74:399-412
Raju S, Naik KBK, Anand Kumar B and Rao GN (2012) Speciation of binary complexes of L-glutamic acid with Co(II), Ni(II) and Cu(II) in low dielectric media. J. Indian Chem. Soc 89:57-62
Rao GN (1989) Ph. D. Thesis, Andhra University, Visakhapatnam, India
Gans P, Sabatini A and Vacca A, (1976) An improved computer program for the computation of formation con-stants from potentiometric data. Inorg. Chim. Acta 18:237-239
Rao GN, Ramana KV and Rao RS (1991) Computer augmented modeling of complexes of amino acids in aqua-organic mixtures. J. Indian Chem. Soc. 68: 34-41
Latha MP, Rao VM, Rao TS and Rao GN (2007) Determination of protonation constants of L-glutamic acid and L-methionine in 1,2 propanediol-water mixtures. Acta Chim. Slov. 54:160-165
Rao GN and Rao RS (1995) Characteristics of water-organic solvent mixtures. J. Teach. Res. Chem. 2: 15-28
Born M (1920) Volume and hydration heat of ions. Z. Phys. 1:45-47
Published
How to Cite
Issue
Section
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright © Author(s) retain the copyright of this article.
