In Vitro anti-inflammatory activity of Various Extracts from Trianthema decandra Linn.,

Abstract

Trianthema decandra Linn. belongs to family Aizoaceae, commonly known as “Gadabandi” in Hindi & “Punarnani” in
Sanskrit. This plant is globally distributed in Indo-Malaysia, Burma and Australia. Within India, it is found in the Rajasthan,
Uttar Pradesh up to Haryana. By looking the high traditional use of the plant Trianthema decandra Linn, The crude extract
of the whole plant has been reported to be superior as a wound dressing material. The leaf extract has been used in the
treatment of chronic pain of osteoarthritic patients. This plant is mainly used in the as analgesic, antimicrobial and
inflammation. Preliminary Phytochemical screening reported the presence of alkaloids, phytosterols, flavonoids, saponins,
tannins and phenolic compounds in the chloroform and methanol extracts of the plant. For screening the anti-inflammatory
activity we used In-vitro method i.e. HRBC membrane stabilizing activity. In this method we compare the HRBC
membrane stabilizing activity for both the chloroform and methanol extract, the Methanolic extract showed the better
activity than the Chloroform extract. Both the extracts showed statistically significant (P<0.01) values in the dose dependent
manner when compared with standard Diclofenac sodium. At 500?g and 400?g the percentage protection of methanolic
extract and standard Diclofenac sodium was found to be 72.15 ± 1.58, 71.20±0.89, 75.63±0.81 & 71.51 ± 0.82 respectively.